Circulating APP, NCAM and Aβ serve as biomarkers for Alzheimer's disease

被引：9

作者：

Chen, Keping ^{[1
]}

Gao, Tianli ^{[1
]}

Bai, Zhimao ^{[2
]}

Yuan, Zuanning ^{[3
]}

机构：

[1] Southeast Univ, Zhongda Hosp, Sch Med, Nanjing 210009, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing 210009, Jiangsu, Peoples R China

[3] Van Andel Res Inst, Grand Rapids, MI 49503 USA

来源：

BRAIN RESEARCH | 2018年 / 1699卷

基金：

中国国家自然科学基金;

关键词：

Circulating biomarker; Alzheimer's disease; Amyloid-precursor protein; Neural cell adhesion molecule; beta-Amyloid; AMYLOID-PRECURSOR PROTEIN; CELL-ADHESION MOLECULE; N-CAM; SCHIZOPHRENIA; SERUM; PLATELET; DEMENTIA; HEALTH; CSF;

D O I：

10.1016/j.brainres.2018.08.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is the most common neurodegenerative disease and the early diagnosis and intervention are important for valid treatment of AD. However, there are few biomarkers for the diagnosis and monitoring of AD. In the present study, circulating APP, NCAM, A beta 40, and A beta 42 were measured in order to identify which marker or combination of markers could be useful, cost-effective and noninvasive biomarkers for diagnosing and continuously monitoring AD. The results showed that circulating APP, NCAM, A beta 40, and A beta 42 were different between the AD group and the control group. Importantly, the combination of the four biomarkers had the highest AUC (0.997) with the highest sensitivity (98.5). Therefore, circulating APP, NCAM, A beta 40, and A beta 42 can be used as desirable biomarkers for AD diagnosis and monitoring.

引用

页码：117 / 120

页数：4

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