Model systems for flavoenzyme activity: Interplay of hydrogen bonding and aromatic stacking in cofactor redox modulation

被引：42
作者：
Gray, M
Goodman, AJ
Carroll, JB
Bardon, K
Markey, M
Cooke, G
Rotello, VM [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
[2] Heriot Watt Univ, Sch Engn & Phys Sci, Dept Chem, Ctr Biomimet Design & Synth, Edinburgh EH14 4AS, Midlothian, Scotland
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 03期
关键词：
D O I：
10.1021/ol036279g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and pi-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.
引用
收藏
页码：385 / 388
页数：4
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