The Role of the Microbiome in Gastrointestinal Cancer

被引：55

作者：

Wroblewski, Lydia E. ^{[1
]}

Peek, Richard M., Jr. ^{[1
]}

Coburn, Lori A. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Div Gastroenterol, 2215 Garland Ave, Nashville, TN 37232 USA

[2] Vet Affairs Tennessee Valley Healthcare Syst, 1310 24th Ave South, Nashville, TN 37212 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2016年 / 45卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Helicobacter pylori; Gastric adenocarcinoma; Microbiota; Pyrosequencing; Colon cancer; Inflammation; HELICOBACTER-PYLORI VACA; GASTRIC-CANCER; GUT MICROBIOTA; COLORECTAL-CANCER; MOLECULAR CHARACTERIZATION; INTESTINAL MICROBIOTA; INFLAMMATION; ASSOCIATION; ESOPHAGUS; DISEASE;

D O I：

10.1016/j.gtc.2016.04.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Humans are host to complex microbial communities previously termed normal flora and largely overlooked. However, resident microbes contribute to both health and disease. Investigators are beginning to define microbes that contribute to the development of gastrointestinal malignancies and the mechanisms by which this occurs. Resident microbes can induce inflammation, leading to cell proliferation and altered stem cell dynamics, which can lead to alterations in DNA integrity and immune regulation and promote carcinogenesis. Studies in human patients and rodent models of cancer have identified alterations in the microbiota of the stomach, esophagus, and colon that increase the risk for malignancy.

引用

页码：543 / +

页数：15

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