Synthesis of Heterocycles through a Ruthenium-Catalyzed Tandem Ring-Closing Metathesis/Isomerization/N-Acyliminium Cyclization Sequence

被引：72

作者：

Ascic, Erhad ^{[1
]}

Jensen, Jakob F. ^{[1
]}

Nielsen, Thomas E. ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 22期

关键词：

cyclization; isomerization; metathesis; ruthenium; tandem reactions; METATHESIS-OLEFIN ISOMERIZATION; IMIDO ALKYLIDENE COMPLEXES; IONS; DERIVATIVES; MOLYBDENUM; REDUCTION; CASCADES;

D O I：

10.1002/anie.201100417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tandem bicycle: In the title reaction double bonds created during ring-closing metathesis isomerize to generate reactive iminium intermediates that undergo intramolecular cyclization reactions with tethered heteroatom and carbon nucleophiles. In this way, a series of biologically interesting heterocyclic compounds can be made, including a known precursor for the total synthesis of the antiparasitic natural product harmicine. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5188 / 5191

页数：4

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