Therapy-related acute lymphoblastic leukemia with MLL rearrangement following treatment of Burkitt's leukemia

被引:3
作者
Millot, F
Brizard, F
Sorel, N
Preudhomme, C
Cividin, M
Guilhot, F
Brizard, A
机构
[1] CHU Poitiers, Serv Oncol Hematol & Therap Cellulaire, F-86000 Poitiers, France
[2] Univ Hosp Lille, Hematol Lab, Lille, France
[3] Univ Hosp Poitiers, Hematol Lab, Poitiers, France
关键词
DNA topoisomerase II inhibitors; therapy-related leukemia; Burkitt's leukemia; children;
D O I
10.1080/10428190500052248
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The occurrence of therapy-related acute lymphoblastic leukemia ( ALL) is rare and, to our knowledge, is not reported in patients treated for Burkitt's leukemia. We report on a child with ALL with translocation t( 4; 11)( q21; q23) involving the MLL gene, 13 months after chemotherapy for Burkitt's leukemia. This present observation indicates that caution should be exercised in using high cumulative doses of DNA topoisomerase II inhibitors in such patients.
引用
收藏
页码:925 / 927
页数:3
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