Foxa2: The rise and fall of dopamine neurons

被引：30
作者：
Arenas, Ernest [1 ]
机构：
[1] Karolinska Inst, Mol Neurobiol Lab, MBB, Ctr Excellence Dev Biol, S-17177 Stockholm, Sweden
来源：
CELL STEM CELL | 2008年 / 2卷 / 02期
关键词：
D O I：
10.1016/j.stem.2008.01.012
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa(2+/-) mice spontaneously develop Parkinsonism.
引用
收藏
页码：110 / 112
页数：3
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