A Convenient Strategy for Remote C-H Bond Halogenation of 8-Aminoquinolines in the C5 Position

被引：14

作者：

Chen, Xiang-Xiang ^{[1
]}

Wang, Jia-Xin ^{[1
]}

Ren, Jiang-Tao ^{[1
]}

Xie, Hu ^{[1
]}

Zhao, Yanxia ^{[1
]}

Li, Ya-Min ^{[2
]}

Sun, Meng ^{[1
]}

机构：

[1] Northwest Univ, Dept Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

来源：

SYNLETT | 2017年 / 28卷 / 14期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

transition-metal-free; halogenation; C-H bond functionalization; aminoquinolines; regioselectivity; potassium persulfate; QUINOLINE N-OXIDES; MILD CONDITIONS; BIFUNCTIONAL ORGANOCATALYSTS; DIRECT ALKYLATION; SODIUM-HALIDES; ARYLATION; DERIVATIVES; ACTIVATION; AMMOSAMIDES; PYRIDINES;

D O I：

10.1055/s-0036-1588420

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient and convenient strategy has been developed for remote C-H bond halogenation of 8-aminoquinolines in good to excellent yields under transition-metal-free conditions. The reaction tolerates a variety of functional groups and can potentially be scaled up.

引用

收藏

页码：1840 / 1844

页数：5

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