Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

被引：132

作者：

Bartholomay, Lyric C. ^{[2
]}

Waterhouse, Robert M. ^{[3
,4
,17
]}

Mayhew, George F. ^{[5
]}

Campbell, Corey L. ^{[6
]}

Michel, Kristin ^{[7
]}

Zou, Zhen ^{[8
]}

Ramirez, Jose L. ^{[9
]}

Das, Suchismita ^{[9
]}

Alvarez, Kanwal ^{[8
]}

Arensburger, Peter ^{[10
]}

Bryant, Bart ^{[7
,8
]}

Chapman, Sinead B. ^{[1
,11
]}

Dong, Yuemei ^{[9
]}

Erickson, Sara M. ^{[5
]}

Karunaratne, S. H. P. Parakrama ^{[12
,13
,14
]}

Kokoza, Vladimir ^{[8
]}

Kodira, Chinnappa D. ^{[15
]}

Pignatelli, Patricia ^{[12
]}

Shin, Sang Woon ^{[8
]}

Vanlandingham, Dana L. ^{[16
]}

Atkinson, Peter W. ^{[10
]}

Birren, Bruce ^{[1
]}

Christophides, George K. ^{[17
]}

Clem, Rollie J. ^{[7
]}

Hemingway, Janet ^{[12
]}

Higgs, Stephen ^{[16
]}

Megy, Karine ^{[18
]}

Ranson, Hilary ^{[12
]}

Zdobnov, Evgeny M. ^{[3
,4
,17
]}

Raikhel, Alexander S. ^{[8
]}

Christensen, Bruce M. ^{[5
]}

Dimopoulos, George ^{[9
]}

Muskavitch, Marc A. T. ^{[1
,19
,20
]}

机构：

[1] Broad Inst, Cambridge, MA 02142 USA

[2] Iowa State Univ, Dept Entomol, Ames, IA 50011 USA

[3] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

[4] Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland

[5] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA

[6] Colorado State Univ, Microbiol Immunol & Pathol Dept, Ft Collins, CO 80523 USA

[7] Kansas State Univ, Arthropod Genom Ctr, Div Biol, Mol & Cellular Dev Biol Program, Manhattan, KS 66506 USA

[8] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA

[9] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Malaria Res Inst, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[10] Univ Calif Riverside, Ctr Dis Vector Res, Dept Entomol, Riverside, CA 92521 USA

[11] Broad Inst, Cambridge, MA 02142 USA

[12] Univ Liverpool Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[13] Univ Peradeniya, Fac Sci, Peradeniya 20400, LK, Sri Lanka

[14] Univ Peradeniya, Dept Zool, Peradeniya 20400, LK, Sri Lanka

[15] 454 Life Sci, Branford, CT 06405 USA

[16] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[17] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, England

[18] European Bioinformat Inst EMBL, Cambridge CB10 1SD, England

[19] Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA

[20] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

SCIENCE | 2010年 / 330卷 / 6000期

基金：

美国国家卫生研究院; 瑞士国家科学基金会; 英国惠康基金;

关键词：

MOSQUITO AEDES-AEGYPTI; INNATE IMMUNE-RESPONSE; ANOPHELES-GAMBIAE; DIPTERA-CULICIDAE; RNA INTERFERENCE; VECTOR MOSQUITOS; VIRUS-INFECTION; HEMOCYTES; DEFENSE; PATHWAY;

D O I：

10.1126/science.1193162

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

引用

页码：88 / 90

页数：3

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