Polymorphism between HLA-A0301 and A0302 located outside the pocket F alters the PΩ peptide motif

被引：8

作者：

Elamin, N. E. ^{[1
]}

Bade-Doeding, C. ^{[1
]}

Blasczyk, R. ^{[1
]}

Eiz-Vesper, B. ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Transfus Med, D-30625 Hannover, Germany

来源：

TISSUE ANTIGENS | 2010年 / 76卷 / 06期

关键词：

auxiliary anchor; peptide-binding motif; polymorphism; stem cell transplantation; T-CELL RECOGNITION; CLASS-I; LIGANDS; BINDING; HLA-B44;

D O I：

10.1111/j.1399-0039.2010.01547.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Soluble recombinant A*0302 was expressed, affinity purified and the bound peptides were then eluted and analysed by mass spectrometry. The peptide-binding motif of A*0302 differs significantly from the previously published HLA-A*0301 and the Glu152Val/Leu156Gln mismatches appear to have a significant impact on the peptide-binding features of A*0302 and A*0301.

引用

页码：487 / 490

页数：4

共 17 条

[1] A single amino-acid polymorphism in pocket A of HLA-A*6602 alters the auxiliary anchors compared with HLA-A*6601 ligands [J].

Bade-Doeding, C ;

Elsner, HA ;

Eiz-Vesper, B ;

Seltsam, A ;

Holtkamp, U ;

Blasczyk, R .

IMMUNOGENETICS, 2004, 56 (02) :83-88

[2] Amino acid 95 causes strong alteration of peptide position PΩ in HLA-B*41 variants [J].

Bade-Doeding, Christina ;

DeLuca, David S. ;

Seltsam, Axel ;

Blasczyk, Rainer ;

Eiz-Vesper, Britta .

IMMUNOGENETICS, 2007, 59 (04) :253-259

[3] The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length [J].

Bell, Melissa J. ;

Burrows, Jacqueline M. ;

Brennan, Rebekah ;

Miles, John J. ;

Tellam, Judy ;

McCluskey, James ;

Rossjohn, Jamie ;

Khanna, Rajiv ;

Burrows, Scott R. .

MOLECULAR IMMUNOLOGY, 2009, 46 (8-9) :1911-1917

[4] Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition [J].

Burrows, Jacqueline M. ;

Bell, Melissa J. ;

Brennan, Rebekah ;

Miles, John J. ;

Khanna, Rajiv ;

Burrows, Scott R. .

MOLECULAR IMMUNOLOGY, 2008, 45 (06) :1818-1824

[5] Have we cut ourselves too short in mapping CTL epitopes? [J].

Burrows, SR ;

Rossjohn, J ;

McCluskey, J .

TRENDS IN IMMUNOLOGY, 2006, 27 (01) :11-16

[6] A roadmap for HLA-A, HLA-B, and HLA-C peptide binding specificities [J].

Chelvanayagam, G .

IMMUNOGENETICS, 1996, 45 (01) :15-26

[7] ENDOGENOUS PEPTIDES BOUND TO HLA-A3 POSSESS A SPECIFIC COMBINATION OF ANCHOR RESIDUES THAT PERMIT IDENTIFICATION OF POTENTIAL ANTIGENIC PEPTIDES [J].

DIBRINO, M ;

PARKER, KC ;

SHILOACH, J ;

KNIERMAN, M ;

LUKSZO, J ;

TURNER, RV ;

BIDDISON, WE ;

COLIGAN, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) :1508-1512

[8] ALLELE-SPECIFIC MOTIFS REVEALED BY SEQUENCING OF SELF-PEPTIDES ELUTED FROM MHC MOLECULES [J].

FALK, K ;

ROTZSCHKE, O ;

STEVANOVIC, S ;

JUNG, G ;

RAMMENSEE, HG .

NATURE, 1991, 351 (6324) :290-296

[9] BONE-MARROW ALLOGRAFT-REJECTION BY LYMPHOCYTES-T RECOGNIZING A SINGLE AMINO-ACID DIFFERENCE IN HLA-B44 [J].

FLEISCHHAUER, K ;

KERNAN, NA ;

OREILLY, RJ ;

DUPONT, B ;

YANG, SY .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (26) :1818-1822

[10]

HIROSAWA M, 1993, COMPUT APPL BIOSCI, V9, P161

← 1 2 →

Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters the PΩ peptide motif

Polymorphism between HLA-A0301 and A0302 located outside the pocket F alters the PΩ peptide motif