Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression

被引：101
作者：
Qin, Jie [1 ]
Liu, Yan [2 ]
Lu, Yongkui [2 ]
Liu, Meiling [2 ]
Li, Manli [2 ]
Li, Juan [2 ]
Wu, Lijuan [2 ]
机构：
[1] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Reprod Med & Genet, Obstet & Gynecol, Nanning, Peoples R China
[2] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Breast & Bone Tissue Oncol, Nanning, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
中国国家自然科学基金;
关键词：
METASTASIS; PROGNOSIS; MIGRATION; INVASION; MARKER; EMT;
D O I：
10.1038/s41598-017-09244-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ovarian cancer have a poor overall survival rate in patients, and late disease presentation and chemoresistance are the main factors that lead to the mortality of ovarian cancer. Cancer stem cells (CSCs), a small subpopulation of cancer cells, have been associated with resistance to chemo- and radio-therapy in cancer treatment. Hypoxia is a common characteristic of many malignant tumors, and increased HIF-1 alpha expression predicts the poor prognosis of ovarian cancer. In this study, we reported the relationship between hypoxia and cancer stem cells-like properties in human ovarian cancer cell lines SKOV3 and HO8910, we found that hypoxia induced cancer stem cells-like properties in ovarian cancer cells. Moreover, SIRT1 was found to be the downstream target gene of HIF-1 alpha, which was involved in the promotion of cancer stem cells-like features in ovarian cancer cells by hypoxia, and NF-kappa B signaling pathway was involved in hypoxia-induced SIRT1 up-regulation. Our results hinted that HIF1 alpha and SIRT1 might serve as potential therapeutic targets for ovarian cancer.
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页数：12
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