Epidemiology of Atopic Dermatitis and Atopic March in Children

被引:195
作者
Spergel, Jonathan M. [1 ]
机构
[1] Univ Penn, Div Allergy & Immunol, Childrens Hosp Philadelphia, Sch Med, Philadelphia, PA 19104 USA
关键词
Atopic dermatitis; Atopic march; Epidemiology; OF-FUNCTION MUTATIONS; PROSPECTIVE FOLLOW-UP; MAJOR RISK-FACTOR; 1ST; 6; YEARS; YOUNG-CHILDREN; NATURAL COURSE; CHILDHOOD ISAAC; ASTHMA; FILAGGRIN; SENSITIZATION;
D O I
10.1016/j.iac.2010.06.003
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Atopic dermatitis (AD) is one of the most common chronic childhood skin diseases affecting up to 17% of children in the United States. The point prevalence of AD has increased based on validated questionnaires in the most recent update of the International Study of Asthma and Allergies in Childhood. However, the increases are primarily in developing countries, whereas the rates have stabilized in countries with higher incomes. AD starts in early childhood with 65% of children affected by 18 months of age. Furthermore, less than half of the patients with AD have complete resolution by 7 years of age and only 60% have resolution by adulthood, indicating the chronic nature of AD. AD is a major risk factor for the development of asthma, with an increased odds ratio in children with AD in several longitudinal studies compared with children without AD, and about 30% of patients with AD develop asthma. Patients with atopic sensitization along with eczema are at a higher risk for progressing in the atopic march to asthma. The main risk factors for progression and persistence of asthma are early onset and severity of AD.
引用
收藏
页码:269 / +
页数:13
相关论文
共 48 条
[1]   Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses [J].
Akei, Hiroko Saito ;
Brandt, Eric B. ;
Mishra, Anil ;
Strait, Richard T. ;
Finkelman, Fred D. ;
Warrier, Manoj R. ;
Hershey, Gurjit K. Khurana ;
Blanchard, Carine ;
Rothenberg, Marc E. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :62-69
[2]   Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys [J].
Asher, M. Innes ;
Montefort, Stephen ;
Bjorksten, Bengt ;
Lai, Christopher K. W. ;
Strachan, David P. ;
Weiland, Stephan K. ;
Williams, Hywel .
LANCET, 2006, 368 (9537) :733-743
[3]   INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) - RATIONALE AND METHODS [J].
ASHER, MI ;
KEIL, U ;
ANDERSON, HR ;
BEASLEY, R ;
CRANE, J ;
MARTINEZ, F ;
MITCHELL, EA ;
PEARCE, N ;
SIBBALD, B ;
STEWART, AW ;
STRACHAN, D ;
WEILAND, SK ;
WILLIAMS, HC .
EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (03) :483-491
[4]   Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood [J].
Barker, Jonathan N. W. N. ;
Palmer, Colin N. A. ;
Zhao, Yiwei ;
Liao, Haihui ;
Hull, Peter R. ;
Lee, Simon P. ;
Allen, Michael H. ;
Meggitt, Simon J. ;
Reynolds, Nicholas J. ;
Trembath, Richard C. ;
McLean, W. H. Irwin .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (03) :564-567
[5]   Childhood atopic eczema [J].
Barnetson, RS ;
Rogers, M .
BRITISH MEDICAL JOURNAL, 2002, 324 (7350) :1376-1379
[6]   Toward a major risk factor for atopic eczema:: Meta-analysis of filaggrin polymorphism data [J].
Baurecht, Hansjoerg ;
Irvine, Alan D. ;
Novak, Natalija ;
Illig, Thomas ;
Buehler, Bettina ;
Ring, Johannes ;
Wagenpfeil, Stefan ;
Weidinger, Stephan .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (06) :1406-1412
[7]   Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema:: ISAAC [J].
Beasley, R ;
Keil, U ;
von Mutius, E ;
Pearce, N ;
Aït-Khaled, N ;
Anabwani, G ;
Anderson, HR ;
Asher, MI ;
Björkstéin, B ;
Burr, ML ;
Clayton, TO ;
Crane, J ;
Ellwood, P ;
Lai, CKW ;
Mallol, J ;
Martinez, FD ;
Mitchell, EA ;
Montefort, S ;
Robertson, CF ;
Shah, JR ;
Sibbald, B ;
Stewart, AW ;
Strachan, DP ;
Weiland, SK ;
Williams, HC .
LANCET, 1998, 351 (9111) :1225-1232
[8]   A clinical index to define risk of asthma in young children with recurrent wheezing [J].
Castro-Rodríguez, JA ;
Holberg, CJ ;
Wright, AL ;
Martinez, FD .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (04) :1403-1406
[9]   New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene-environment interactions [J].
Cork, Michael J. ;
Robinson, Darren A. ;
Vasilopoulos, Yiannis ;
Ferguson, Adam ;
Moustafa, Manar ;
MacGowan, Alice ;
Duff, Gordon W. ;
Ward, Simon J. ;
Tazi-Ahnini, Rachid .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :3-21
[10]   Skin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma [J].
Demehri, Shadmehr ;
Morimoto, Mitsuru ;
Holtzman, Michael J. ;
Kopan, Raphael .
PLOS BIOLOGY, 2009, 7 (05)