Investigating the Mechanical Properties of Biological Brain Cells With Atomic Force Microscopy

被引：3

作者：

Bahwini, Tariq Mohana ^{[1
]}

Zhong, Yongmin ^{[1
]}

Gu, Chengfan ^{[2
]}

Nasa, Zeyad ^{[3
]}

Oetomo, Denny ^{[2
]}

机构：

[1] RMIT Univ, Sch Engn, Melbourne, Vic 3083, Australia

[2] Univ Melbourne, Dept Mech Engn, Parkville, Vic 3010, Australia

[3] RMIT, Micro Nano Res Facil, Coll Sci Engn & Hlth, Melbourne, Vic 3000, Australia

来源：

JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME | 2018年 / 12卷 / 04期

关键词：

PROLIFERATION; SYSTEM;

D O I：

10.1115/1.4040995

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Characterization of cell mechanical properties plays an important role in disease diagnoses and treatments. This paper uses advanced atomic force microscopy (AFM) to measure the geometrical and mechanical properties of two different human brain normal HNC-2 and cancer U87 MG cells. Based on experimental measurement, it measures the cell deformation and indentation force to characterize cell mechanical properties. A fitting algorithm is developed to generate the force-loading curves from experimental data. An inverse Hertzian method is also established to identify Young's moduli for HNC-2 and U87 MG cells. The results demonstrate that Young's modulus of cancer cells is different from that of normal cells, which can help us to differentiate normal and cancer cells from the biomechanical viewpoint.

引用

页数：12

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