Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

被引：5
|
作者：
Ingale, Ajit P. [1 ]
Garad, Dnyaneshwar N. [2 ]
Ukale, Dattatraya [3 ]
Thorat, Nitin M. [4 ]
Shinde, Sandeep, V [5 ]
机构：
[1] Savitribai Phule Pune Univ, Dada Patil Coll, Dept Chem, Ahmednagar, Maharashtra, India
[2] Natl Univ Ireland Galway, Sch Chem, Galway, Ireland
[3] Univ Oxford, Dept Chem, Oxford, England
[4] Savitribai Phule Pune Univ, Maharaja Jivajirao Shinde Coll, Dept Chem, Shrigonda, Ahmednagar, India
[5] Swami Ramanand Teerth Marathwada Univ, Pratibha Niketan Coll, Dept Chem, Nanded, India
来源：
SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 24期
关键词：
Chemoselective; eco-friendly; N-tert butyloxycarbonylation; recyclable; thiamin hydrochloride; ONE-POT SYNTHESIS; CATALYZED BOC PROTECTION; HIGHLY EFFICIENT; IONIC LIQUID; BUTYL DICARBONATE; REUSABLE CATALYST; ARYL AMINES; ACID; BUTOXYCARBONYLATION; MILD;
D O I：
10.1080/00397911.2021.1994998
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly.
引用
收藏
页码：3791 / 3804
页数：14
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