Crosstalk between Sertoli and Germ Cells in Male Fertility

被引：117
作者：
Wu, Siwen [1 ,2 ,3 ]
Yan, Ming [4 ]
Ge, Renshan [1 ,2 ]
Cheng, C. Yan [1 ,2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China
[3] Populat Council, Ctr Biomed Res, Mary M Wohlford Lab Male Contracept Res, 1230 York Ave, New York, NY 10065 USA
[4] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 02期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
BLOOD-TESTIS BARRIER; F-ACTIN ORGANIZATION; SEMINIFEROUS EPITHELIUM; EXTRACELLULAR-MATRIX; JUNCTION DYNAMICS; LIFE-HISTORY; ECTOPLASMIC SPECIALIZATION; SIGNALING MECHANISMS; MAMMALIAN TARGET; AUTOCRINE AXIS;
D O I：
10.1016/j.molmed.2019.09.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which takes place in the epithelium of seminiferous tubules. Sertoli cells, also known as 'mother' or 'nurse' cells, provide nutrients, paracrine factors, cytokines, and other biomolecules to support gear cell development. Sertoli cells facilitate the generation of several biologically active peptides, which include F5-, noncoflagenous 1 (NC1)-, and laminin globular (LG)3/4/5-peptide, to modulate cellular events across the epithelium. Here, we critically evaluate the involvement of these pep tides in facilitating crosstalk between Sertoli and germ cells to support spermatogenesis anc thus fertility. Modulating or mimicking the activity of F5-, NC1-, and LG3/4/5-peptide could be used to enhance the transport across the blood-testis barrier (BTB) of contraceptive drugs of to treat male infertility.
引用
收藏
页码：215 / 231
页数：17
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