SIRT3 and cancer: Tumor promoter or suppressor?

被引：157
作者：
Alhazzazi, Turki Y. [1 ]
Kamarajan, Pachiyappan [1 ]
Verdin, Eric [2 ]
Kapila, Yvonne L. [1 ]
机构：
[1] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA
[2] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2011年 / 1816卷 / 01期
关键词：
Sirtuin-3; SIRT3; Cancer; Tumor promoter; Tumor suppressor; HISTONE DEACETYLASE INHIBITORS; IN-SITU HYBRIDIZATION; BCL-2 FAMILY PROTEINS; FATTY-ACID OXIDATION; CARCINOMA CELL-LINES; CALORIE RESTRICTION; SIRT3-MEDIATED DEACETYLATION; CHROMOSOMAL ORGANIZATION; INSULIN-SECRETION; DOWN-REGULATION;
D O I：
10.1016/j.bbcan.2011.04.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：80 / 88
页数：9
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