Concise Review: Neutral Endopeptidase (CD10): A Multifaceted Environment Actor in Stem Cells, Physiological Mechanisms, and Cancer

被引:147
作者
Maguer-Satta, Veronique [1 ,2 ,3 ]
Besancon, Roger [1 ,2 ,3 ,4 ]
Bachelard-Cascales, Elodie [1 ,2 ,3 ]
机构
[1] Univ Lyon, F-69007 Lyon, France
[2] INSERM, Ctr Leon Berard, U590, F-69008 Lyon, France
[3] IFR62, F-69008 Lyon, France
[4] Univ Lyon 1, ISPB, F-69008 Lyon, France
关键词
CD10; enzyme; cancer; Microenvironment; Stem cells; Signaling; ACUTE LYMPHOBLASTIC-LEUKEMIA; STROMAL CELLS; CD10/NEUTRAL ENDOPEPTIDASE-24.11; PROSTATE-CANCER; MAMMARY-GLAND; SURFACE PEPTIDASES; PROGNOSTIC-FACTORS; HUMAN BREAST; ORAL-CAVITY; EXPRESSION;
D O I
10.1002/stem.592
中图分类号
Q813 [细胞工程];
学科分类号
摘要
CD10 is a remarkable member of the major class of widely expressed cell surface proteins, endopeptidases. First identified in leukemia as a tumor-specific antigen (common acute lymphoblastic leukemia antigen), CD10 has become largely used in cancer diagnosis. However, its function in oncogenesis remains unclear. We previously identified CD10 as a tool to access sphere-forming cells and showed its involvement in mammary stem cell (SC) regulation. We further illustrated that its enzymatic activity is involved, through signaling peptides, in SC maintenance. Therefore, CD10 is not only a cell surface marker in normal and malignant contexts but also affects the extracellular environment and plays a key role in regulation of a number of biological functions and likely in SC. In tumors, the "niche" favors the survival of sheltered cancer SC whose eradication has become the new challenge in oncology. This highlights the importance of understanding the role of CD10 in cancer SC. We will review the characteristics, main functions, and mechanism of action of CD10. Finally, we will review its clinical use and involvement in cancer. STEM CELLS 2011;29:389-396
引用
收藏
页码:389 / 396
页数:8
相关论文
共 75 条
[1]   CD10 expression in tumour and stromal cells of bladder carcinoma: an association with bilharziasis [J].
Abdou, Asmaa Gaber .
APMIS, 2007, 115 (11) :1206-1218
[2]   IMMUNOLOCALIZATION OF CELL-SURFACE PEPTIDASES IN THE DEVELOPING HUMAN BREAST [J].
ATHERTON, AJ ;
ANBAZHAGAN, R ;
MONAGHAN, P ;
BARTEK, J ;
GUSTERSON, BA .
DIFFERENTIATION, 1994, 56 (1-2) :101-106
[3]   The CD10 Enzyme Is a Key Player to Identify and Regulate Human Mammary Stem Cells [J].
Bachelard-Cascales, Elodie ;
Chapellier, Marion ;
Delay, Emmanuel ;
Pochon, Gaetan ;
Voeltzel, Thibault ;
Puisieux, Alain ;
de Fromentel, Claude Caron ;
Maguer-Satta, Veronique .
STEM CELLS, 2010, 28 (06) :1081-1088
[4]  
BARKER PE, 1989, J IMMUNOL, V142, P283
[5]   Immunophenotyping of acute leukaemias [J].
Béné, MC .
IMMUNOLOGY LETTERS, 2005, 98 (01) :9-21
[6]   CD10 expression in urothelial bladder carcinomas: A pilot study [J].
Bircan, Sema ;
Candir, Ozden ;
Kapucuoglu, Nilgun ;
Serel, T. Ahmet ;
Ciris, Metin ;
Karahan, Nermin .
UROLOGIA INTERNATIONALIS, 2006, 77 (02) :107-113
[7]   Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study [J].
Borowitz, Michael J. ;
Devidas, Meenakshi ;
Hunger, Stephen P. ;
Bowman, W. Paul ;
Carroll, Andrew J. ;
Carroll, William L. ;
Linda, Stephen ;
Martin, Paul L. ;
Pullen, D. Jeanette ;
Viswanatha, David ;
Willman, Cheryl L. ;
Winick, Naomi ;
Camitta, Bruce M. .
BLOOD, 2008, 111 (12) :5477-5485
[8]   Canalicular immunostaining of neprilysin (CD10) as a diagnostic marker for hepatocellular carcinomas [J].
Borscheri, N ;
Roessner, A ;
Röcken, C .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (10) :1297-1303
[9]   Novel markers for the prospective isolation of human MSC [J].
Buehring, Hans-Joerg ;
Battula, Venkata Lokesh ;
Treml, Sabrina ;
Schewe, Bernhard ;
Kanz, Lothar ;
Vogel, Wichard .
HEMATOPOIETIC STEM CELLS VI, 2007, 1106 :262-271
[10]   EXPRESSION OF CALLA/CD10 ON HUMAN-MELANOMA CELLS [J].
CARREL, S ;
ZOGRAFOS, L ;
SCHREYER, M ;
RIMOLDI, D .
MELANOMA RESEARCH, 1993, 3 (05) :319-323