Blood serum levels of amino-terminal pro-C-type natriuretic peptide in patients with rheumatoid arthritis

被引:6
|
作者
Olewicz-Gawlik, A. [1 ]
Trzybulska, D. [1 ]
Grala, P. [2 ]
Hrycaj, P. [1 ]
机构
[1] Poznan Univ Med Sci, Dept Rheumatol & Clin Immunol, PL-60356 Poznan, Poland
[2] Poznan Univ Med Sci, Div Trauma Burns & Plast Surg, PL-60356 Poznan, Poland
来源
ADVANCES IN MEDICAL SCIENCES | 2010年 / 55卷 / 02期
关键词
rheumatoid arthritis; C-type natriuretic peptide; selectins; L-SELECTIN EXPRESSION; DISEASE-ACTIVITY; ENDOTHELIAL-CELLS; LEUKOCYTE RECRUITMENT; SYSTEMIC-SCLEROSIS; P-SELECTIN; PLASMA; SECRETION; DISTINCT; BRAIN;
D O I
10.2478/v10039-010-0036-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Purpose: Angiogenesis is a prominent feature of rheumatoid synovitis and contributes to perpetuation of joint disease. The aim of presented study was to evaluate the association of inflammatory response and endothelial dysfunction parameters with serum levels of amino-terminal pro-C-type natriuretic peptide (NT-proCNP), a surrogate measure for a potent regulator of vascular tone and angiogenesis, CNP. Material/Methods: We included in this study 40 rheumatoid arthritis (RA) patients (36 female, four male) and 30 healthy controls (28 female, two male). Disease activity score (DAS28), Health Assessment Questionnaire Disability Index (HAQDI), Rheumatoid Arthritis Disease Activity Index (RADAI) and visual analogue scales (VAS) for pain and arthritis were determined. The concentrations of the following laboratory parameters (serum C-reactive protein (CRP), soluble (s) L-, sP-, sE-selectin, NT-proCNP, IgM rheumatoid factor (RF), and anti-cyclic citrullinated peptide antibodies) were measured using sandwich enzyme-linked immunosorbent assay (ELISA). Results: The concentrations of NT-proCNP in RA patients were significantly increased when compared to healthy controls (p<0.001). In RA patients we found significant correlations only between sE-selectin and NT-proCNP levels (p=0.02). No significant associations were found between serum NT-proCNP and soluble selectin levels and patients' age and sex. Also, the parameters of clinical profile in the RA group (HAQ, RADAI, DAS28, VAS-pain, VAS-arthritis, swollen and tender joint counts) showed no association with serum NT-proCNP, sE-, sP- and sL-selectin. Conclusions: Serum concentration of NT-proCNP reflecting serum CNP level is likely secondary to the activation of endothelium. Nevertheless, the results of our study encourage to further studies over the role of CNP in the pathogenesis of RA, preferably on tissue level.
引用
收藏
页码:261 / 265
页数:5
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