Repurposing ribosome-targeting antibiotics to overcome resistance to venetoclax in acute myeloid leukemia

被引：1
|
作者：
Sharon, David [1 ]
Chan, Steven M. [1 ]
机构：
[1] Princess Margaret Canc Ctr, Dept Hematol & Med Oncol, Toronto, ON, Canada
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2020年 / 7卷 / 02期
基金：
加拿大健康研究院;
关键词：
Acute myeloid leukemia; BCL-2; inhibitor; drug resistance; integrated stress response; antibiotics; mitochondrial translation; ABT-199;
D O I：
10.1080/23723556.2020.1712182
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Venetoclax, a selective B-cell lymphoma 2 inhibitor, has shown promise in the treatment of acute myeloid leukemia. However, the development of drug resistance limits its clinical efficacy. In our study, we discovered that ribosome-targeting antibiotics can be repurposed to overcome venetoclax resistance in AML cells through activation of the integrated stress response.
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页数：3
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