How can the structure of germinal-center kinase-like kinase help us in drug discovery?

被引：0

作者：

Silvian, Laura ^{[1
]}

机构：

[1] Biogen, 225 Binney St, Cambridge, MA 02142 USA

来源：

FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 14期

关键词：

activation loop-swapped dimer; germinal-center kinase-like kinase; GLK; immunological synapse; inhibitor; Map4k3; PP2A PR61(epsilon) substrate; ACTIVATION;

D O I：

10.4155/fmc-2017-0133

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1583 / 1585

页数：3

共 9 条

[1] The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB [J].

Biondi, RM ;

Kieloch, A ;

Currie, RA ;

Deak, M ;

Alessi, DR .

EMBO JOURNAL, 2001, 20 (16) :4380-4390

[2] Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker [J].

Chen, Der-Yuan ;

Chuang, Huai-Chia ;

Lan, Joung-Liang ;

Chen, Yi-Ming ;

Hung, Wei-Ting ;

Lai, Kuo-Lung ;

Tan, Tse-Hua .

BMC MEDICINE, 2012, 10

[3] The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells [J].

Chuang, Huai-Chia ;

Lan, Joung-Liang ;

Chen, Der-Yuan ;

Yang, Chia-Yu ;

Chen, Yi-Ming ;

Li, Ju-Pi ;

Huang, Ching-Yu ;

Liu, Pao-En ;

Wang, Xiaohong ;

Tan, Tse-Hua .

NATURE IMMUNOLOGY, 2011, 12 (11) :1113-U121

[4] Happyhour, a Ste20 Family Kinase, Implicates EGFR Signaling in Ethanol-Induced Behaviors [J].

Corl, Ammon B. ;

Berger, Karen H. ;

Ophir-Shohat, Galit ;

Gesch, Julie ;

Simms, Jeffrey A. ;

Bartlett, Selena E. ;

Heberlein, Ulrike .

CELL, 2009, 137 (05) :949-960

[5] Drosophila happyhour modulates JNK-dependent apoptosis [J].

Lam, D. ;

Shah, S. ;

De Castro, I. P. ;

Loh, S. H. Y. ;

Martins, L. M. .

CELL DEATH & DISEASE, 2010, 1 :e66-e66

[6] Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension [J].

Marcotte, Douglas ;

Rushe, Mia ;

Arduini, Robert M. ;

Lukacs, Christine ;

Atkins, Kateri ;

Sun, Xin ;

Little, Kevin ;

Cullivan, Michael ;

Paramasivam, Murugan ;

Patterson, Thomas A. ;

Hesson, Thomas ;

Mckee, Timothy D. ;

May-Dracka, Tricia L. ;

Xin, Zhili ;

Bertolotti-Ciarlet, Andrea ;

Bhisetti, Govinda R. ;

Lyssikatos, Joseph P. ;

Silvian, Laura F. .

PROTEIN SCIENCE, 2017, 26 (02) :152-162

[7] Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors [J].

Wang, Lan ;

Stanley, Mark ;

Boggs, Jason W. ;

Crawford, Terry D. ;

Bravo, Brandon J. ;

Giannetti, Anthony M. ;

Harris, Seth F. ;

Magnuson, Steven R. ;

Nonomiya, Jim ;

Schmidt, Stephen ;

Wu, Ping ;

Ye, Weilan ;

Gould, Stephen E. ;

Murray, Lesley J. ;

Ndubaku, Chudi O. ;

Chen, Huifen .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (18) :4546-4552

[8] Signalling by amino acid nutrients [J].

Yan, Lijun ;

Lamb, Richard F. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2011, 39 :443-445

[9] PP2AT61ε Is an Inhibitor of MAP4K3 in Nutrient Signaling to mTOR [J].

Yan, Lijun ;

Mieulet, Virginie ;

Burgess, Darren ;

Findlay, Greg M. ;

Sully, Katherine ;

Procter, Julia ;

Goris, Jozef ;

Janssens, Veerle ;

Morrice, Nick A. ;

Lamb, Richard F. .

MOLECULAR CELL, 2010, 37 (05) :633-642

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