FK506-associated limbic injury following umbilical cord blood transplantation

被引：0

作者：

Yoshida, Y ^{[1
]}

Shimada, H ^{[1
]}

Mori, T ^{[1
]}

Yoshihara, H ^{[1
]}

Takeoka, M ^{[1
]}

Takahashi, T ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Pediat, Shinjuku Ku, Tokyo 1608582, Japan

来源：

BONE MARROW TRANSPLANTATION | 2003年 / 32卷 / 05期

关键词：

limbic injury; FK506; cyclosporin A; immunophilin; DWI;

D O I：

10.1038/sj.bmt.1704168

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.

引用

页码：523 / 525

页数：3

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