Tamoxifen Therapy for Recurrent Mucosal Bleeding in Hereditary Hemorrhagic Telangiectasia

被引：1

作者：

Yung, Stephanie ^{[1
]}

Bell, Julie-Anne ^{[2
]}

Brooker, Jim ^{[1
]}

机构：

[1] Waikato Hosp, Dept Gastroenterol, Hamilton, New Zealand

[2] Waikato Hosp, Dept Haematol, Hamilton, New Zealand

来源：

JOURNAL OF HEMATOLOGY | 2021年 / 10卷 / 01期

关键词：

Hereditary hemorrhagic telangiectasia; Tamoxifen; Epistaxis; GI bleeding;

D O I：

10.14740/jh794

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 60-year-old Caucasian man had a 55-year history of recurrent severe epistaxis and later presented with multiple gastrointestinal (GI) bleeding from hereditary hemorrhagic telangiectasia (TINT). Bleeding was exacerbated due to coexistent mild hemophilia A. Despite repeated conventional surgical interventions, tranexamic acid and recombinant factor VIII (FVIII) prophylaxis, bleeding episodes worsened in frequency and severity, resulting in the patient becoming transfusion dependent. The introduction of tamoxifen therapy resulted in reduced transfusion requirement.

引用

页码：22 / 24

页数：3

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