A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging

被引：37

作者：

Sarkar, Avik R. ^{[1
,2
]}

Heo, Cheol Ho ^{[1
,2
]}

Kim, Eunjin ^{[3
]}

Lee, Hyo Won ^{[1
,2
]}

Singh, Hardev ^{[1
,2
]}

Kim, Jeong Jin ^{[1
,2
]}

Kang, Hyuk ^{[1
,2
]}

Kang, Chulhun ^{[3
]}

Kim, Hwan Myung ^{[1
,2
]}

机构：

[1] Ajou Univ, Dept Chem, Suwon 443749, South Korea

[2] Ajou Univ, Dept Energy Syst Res, Suwon 443749, South Korea

[3] Kyung Hee Univ, Yongin 446701, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

NEURODEGENERATIVE DISEASES; NEPHROPATHIC CYSTINOSIS; PHOSPHATASE-ACTIVITIES; LIVE CELLS; TISSUES; CYSTEINE; THERAPY; THIOLS; HOMOCYSTEINE; METABOLISM;

D O I：

10.1039/c4cc09416f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a two-photon fluorescent probe for ratiometric imaging of cysteamine in situ. This probe can detect the levels of endogenous cysteamine with statistical significance in live cells and brain hippocampal tissues, revealing that cysteamine is localized mainly in the perikaria of the pyramidal neurons and the granule cells.

引用

页码：2407 / 2410

页数：4

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