Influence of the sequence of administration of β-glucans and a Vibrio damsela vaccine on the immune response of turbot (Scophthalmus maximus L.)

被引：48

作者：

Figueras, A ^{[1
]}

Santarém, MM ^{[1
]}

Novoa, B ^{[1
]}

机构：

[1] CSIC, Inst Invest Marinas, Vigo 36208, Spain

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1998年 / 64卷 / 01期

关键词：

immunostimulant; glucan; turbot; vaccine; immune response;

D O I：

10.1016/S0165-2427(98)00114-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Yeast (Saccharomyces cerevisae) beta-1,3 glucans were used as adjuvant in a Vibrio damsela vaccine for turbot (Scophthalmus maximus L.). Turbot were injected with the adjuvant prior, at the same time and after the vaccine. Several immune parameters (inder and rate of phagocytosis, passive haemolytic plaque numbers, and agglutinating antibody titers) were determined at different times postinoculation. The highest activity of all the immune parameters was obtained when glucans were injected after the bacterin. It is concluded that the sequence of glucan administration is critical when used as a vaccine adjuvant. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：59 / 68

页数：10

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