Enantioselective reduction of substituted acetophenones by Aspergillus niger

被引:33
作者
Kurbanoglu, Eshabi B. [1 ]
Zilbeyaz, Kani
Kurbanoglu, Namudar I.
Kilic, Hamdullah
机构
[1] Ataturk Univ, Dept Biol, TR-25240 Erzurum, Turkey
[2] Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey
[3] Sakarya Univ, Dept Chem, Hendek Fac Educ, Sakarya, Turkey
关键词
D O I
10.1016/j.tetasy.2007.05.017
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Fourteen strains of Aspergillus niger were isolated from soil samples. These isolates were evaluated for tile reduction of acetophenone to 1-phenylethanol. Among the tested isolates, whole cells of the A. niger EBK-9 isolate were found to be an effective biocatalyst for the enantioselective reduction of acetophenone. Under optimized conditions substituted acetophenones were converted to the corresponding optically active alcohol in up to 99% ee. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1159 / 1162
页数:4
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