Activation of Uterine Smad3 Pathway Is Crucial for Embryo Implantation

被引：10
作者：
Li, Juan [1 ,2 ]
Dong, Xi-yuan [1 ]
Yang, Pei-wen [1 ]
Yang, Shu-lin [1 ]
Hu, Dan [1 ]
Zhang, Han-wang [1 ]
Sui, Cong [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan 430030, Peoples R China
[2] Zhejiang Univ, Sch Med, Womens Hosp, Dept Gynecol, Hangzhou 310000, Peoples R China
来源：
CURRENT MEDICAL SCIENCE | 2019年 / 39卷 / 06期
基金：
中国国家自然科学基金;
关键词：
transforming growth factor-betas (TGF-beta s); Smad3; endometrial receptivity; decidualization; embryo implantation; TGF-BETA; BLASTOCYST IMPLANTATION; HUMAN ENDOMETRIUM; DECIDUALIZATION; EXPRESSION; CLUES;
D O I：
10.1007/s11596-019-2134-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Embryo implantation is a complicated physiological process tightly regulated by multiple biological molecules including growth factors. Transforming growth factor-betas (TGF-beta s) and their most specific signal transduction factors, Smads, are expressed in the endometrium during the window of implantation. Recent researches indicated that Smad dependent TGF-beta signaling may play an important role in the process of embryo implantation. In this study, we measured the expression of TGF-beta 1, TGF-beta receptor type I (T beta RI), Smad3 and p-Smad3 in the endometrium of mice and observed their elevation on day 4, 5 and 6 of pseudopregnancy. Then we administrated a specific Smad3 inhibitor (Sis3) into the uterine cavity of mice on day 3 of pregnancy. The results showed a reduction in insulin-like growth factor-1 (IGFBP-1) expression and the decreased number of implanted embryo after the administration. In addition, Sis3 was found to reduce the IGFBP-1 secretion in decidualized endometrial stromal cells. Taken all together, our findings demonstrated that TGF-beta/Smad3 signaling is involved in the process of embryo implantation.
引用
收藏
页码：997 / 1002
页数：6
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