Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer

被引：25

作者：

Honda, Kazufumi ^{[1
,2
]}

Srivastava, Sudhir ^{[3
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Chemotherapy & Clin Res, Tokyo 1040045, Japan

[2] Japan Agcy Med Res & Dev AMED CREST, Tokyo 1000004, Japan

[3] NCI, Canc Prevent Div, Rockville, MD 20852 USA

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 11期

关键词：

apolipoprotein A2 isoforms; early detection for pancreatic cancer; National Cancer Institute Early Detection Research Network; NCI EDRN; plasma/serum biomarker; COHORT-CONSORTIUM PANSCAN; MONOCLONAL-ANTIBODY; POOLED-ANALYSIS; ADENOCARCINOMA; SERUM; BIOMARKER; DIAGNOSIS; PLASMA; GLYPICAN-1; POPULATION;

D O I：

10.2217/bmm-2016-0209

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general population using invasive modalities is not feasible. Combination of invasive screening with noninvasive biomarkers for pancreatic cancer and its precancerous lesions has the potential to reduce mortality due to pancreatic cancer. In this review, we focus on biomarkers found in the blood that can indicate early-stage pancreatic cancer, and we discuss current strategies for screening for pancreatic cancer. We recently identified a unique alteration in apolipoprotein A2 isoforms in pancreatic cancer and its precancerous lesions, and we describe its clinical usefulness as a potential biomarker for the early detection and risk stratification of pancreatic cancer.

引用

页码：1197 / 1207

页数：11

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