Core-Shell Nanocapsules Stabilized by Single-Component Polymer and Nanoparticles for Magneto-Chemotherapy/Hyperthermia with Multiple Drugs

被引：121

作者：

Hu, Shang-Hsiu ^{[1
]}

Liao, Bang-Jie ^{[1
]}

Chiang, Chin-Sheng ^{[1
]}

Chen, Po-Jung ^{[1
]}

Chen, I-Wei ^{[2
]}

Chen, San-Yuan ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan

[2] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 27期

关键词：

double emulsions; nanocapsules; iron oxide nanoparticles; hyperthermia; synergic therapy; DOUBLE EMULSIONS; CANCER; DOXORUBICIN; DELIVERY; RELEASE; NANOCARRIERS; PACLITAXEL; CELLS; SIRNA;

D O I：

10.1002/adma.201201251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3627 / 3632

页数：6

共 26 条

[21] PLGA/polymeric liposome for targeted drug and gene co-delivery [J].