Core-Shell Nanocapsules Stabilized by Single-Component Polymer and Nanoparticles for Magneto-Chemotherapy/Hyperthermia with Multiple Drugs

被引：120
作者：
Hu, Shang-Hsiu [1 ]
Liao, Bang-Jie [1 ]
Chiang, Chin-Sheng [1 ]
Chen, Po-Jung [1 ]
Chen, I-Wei [2 ]
Chen, San-Yuan [1 ]
机构：
[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan
[2] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA
来源：
ADVANCED MATERIALS | 2012年 / 24卷 / 27期
关键词：
double emulsions; nanocapsules; iron oxide nanoparticles; hyperthermia; synergic therapy; DOUBLE EMULSIONS; CANCER; DOXORUBICIN; DELIVERY; RELEASE; NANOCARRIERS; PACLITAXEL; CELLS; SIRNA;
D O I：
10.1002/adma.201201251
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3627 / 3632
页数：6
相关论文
共 26 条
  • [1] Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/NMAT2992, 10.1038/nmat2992]
  • [2] Binks B. P., 2006, COLLOIDAL PARTICLES
  • [3] pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles
    Chen, Wei
    Meng, Fenghua
    Cheng, Ru
    Zhong, Zhiyuan
    [J]. JOURNAL OF CONTROLLED RELEASE, 2010, 142 (01) : 40 - 46
  • [4] A simple method for the preparation of monodisperse protein-loaded microspheres with high encapsulation efficiencies
    Cheng, Xinjian
    Liu, Ruilan
    He, Yinghe
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2010, 76 (03) : 336 - 341
  • [5] The dawning era of polymer therapeutics
    Duncan, R
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) : 347 - 360
  • [6] Some stability criteria for double emulsions
    Ficheux, MF
    Bonakdar, L
    Leal-Calderon, F
    Bibette, J
    [J]. LANGMUIR, 1998, 14 (10) : 2702 - 2706
  • [7] Pharmacokinetics of combined doxorubicin and paclitaxel in mice
    Gustafson, DL
    Merz, AL
    Long, ME
    [J]. CANCER LETTERS, 2005, 220 (02) : 161 - 169
  • [8] Nanoscale double emulsions stabilized by single-component block copolypeptides
    Hanson, Jarrod A.
    Chang, Connie B.
    Graves, Sara M.
    Li, Zhibo
    Mason, Thomas G.
    Deming, Timothy J.
    [J]. NATURE, 2008, 455 (7209) : 85 - U54
  • [9] Multiple Polymersomes for Programmed Release of Multiple Components
    Kim, Shin-Hyun
    Shum, Ho Cheung
    Kim, Jin Woong
    Cho, Jun-Cheol
    Weitz, David A.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (38) : 15165 - 15171
  • [10] Miniemulsion Polymerization and the Structure of Polymer and Hybrid Nanoparticles
    Landfester, Katharina
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (25) : 4488 - 4507
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