The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study

被引：14

作者：

Duan, Z-H ^{[1
]}

Pan, F-M ^{[1
]}

Zeng, Z. ^{[1
]}

Zhang, T-C ^{[1
]}

Wang, S. ^{[1
]}

Li, G-X ^{[1
]}

Mei, Y. ^{[1
]}

Gao, J. ^{[1
]}

Ge, R. ^{[1
]}

Ye, D-Q ^{[1
]}

Zou, Y-F ^{[1
]}

Xu, S-Q ^{[2
]}

Xu, J-H ^{[2
]}

Zhang, L. ^{[3
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Hefei 230032, Anhui, Peoples R China

[3] Anhui Med Coll, Anhui Med Genet Ctr, Hefei, Anhui, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2012年 / 41卷 / 03期

基金：

中国国家自然科学基金;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; GAMMA-RECEPTOR-IIB; GENETIC SUSCEPTIBILITY; RHEUMATOID-ARTHRITIS; INHIBITORY RECEPTORS; B-CELLS; FC; RIIB; EXPRESSION; DISEASE;

D O I：

10.3109/03009742.2011.625972

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS). Method: A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping. Results: SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS. Conclusion: These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.

引用

页码：219 / 222

页数：4

共 25 条

[1] Is there a common genetic basis for autoimmune diseases? [J].

Anaya, Juan-Manuel ;

Gomez, Luismiguel ;

Castiblanco, John .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2006, 13 (2-4) :185-195

[2] Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase [J].

Blom, AB ;

Radstake, TRDJ ;

Holthuysen, AEM ;

Slöetjes, AW ;

Pesman, GJ ;

Sweep, FGJ ;

van de Loo, FAJ ;

Joosten, LAB ;

Barrera, P ;

van Lent, PLEM ;

van den Berg, WB .

ARTHRITIS AND RHEUMATISM, 2003, 48 (04) :1002-1014

[3] Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis [J].

Brown, MA ;

Laval, SH ;

Brophy, S ;

Calin, A .

ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (11) :883-886

[4] Susceptibility to ankylosing spondylitis in twins - The role of genes, HLA, and the environment [J].

Brown, MA ;

Kennedy, LG ;

MacGregor, AJ ;

Darke, C ;

Duncan, E ;

Shatford, JL ;

Taylor, A ;

Calin, A ;

Wordsworth, P .

ARTHRITIS AND RHEUMATISM, 1997, 40 (10) :1823-1828

[5] A transmembrane polymorphism in FcγRIIb (FCGR2B) is associated with the production of anti-cyclic citrullinated peptide autoantibodies in Taiwanese RA [J].

Chen, J-Y ;

Wang, C-M ;

Ma, C-C ;

Hsu, L-A ;

Ho, H-H ;

Wu, Y-J J. ;

Kuo, S-N ;

Wu, J. .

GENES AND IMMUNITY, 2008, 9 (08) :680-688

[6] Physiological up-regulation of inhibitory receptors FcγRII and CR1 on memory B cells is lacking in SLE patients [J].

Isaak, Andrea ;

Gergely, Peter, Jr. ;

Szekeres, Zsuzsanna ;

Prechl, Jozsef ;

Poor, Gyula ;

Erdei, Anna ;

Gergely, Janos .

INTERNATIONAL IMMUNOLOGY, 2008, 20 (02) :185-192

[7] The combined genotypes of stimulatory and inhibitory Fcγ receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults [J].

Kobayashi, Tetsuo ;

Ito, Satoshi ;

Yasuda, Keiko ;

Kuroda, Takeshi ;

Yamamoto, Kouji ;

Sugita, Noriko ;

Tai, Hideaki ;

Narita, Ichiei ;

Gejyo, Fumitake ;

Yoshie, Hiromasa .

JOURNAL OF PERIODONTOLOGY, 2007, 78 (03) :467-474

[8] Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus -: Contribution of FCGR2B to genetic susceptibility [J].

Kyogoku, C ;

Dijstelbloem, HM ;

Tsuchiya, N ;

Hatta, Y ;

Kato, H ;

Yamaguchi, A ;

Fukazawa, T ;

Jansen, MD ;

Hashimoto, H ;

van de Winkel, JGJ ;

Kallenberg, CGM ;

Tokunaga, K .

ARTHRITIS AND RHEUMATISM, 2002, 46 (05) :1242-1254

[9] Fcγ receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis [J].

Lee, Y. H. ;

Ji, J. D. ;

Song, G. G. .

LUPUS, 2009, 18 (08) :727-734

[10] A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling [J].

Li, XL ;

Wu, JM ;

Carter, RH ;

Edberg, JC ;

Su, KH ;

Cooper, GS ;

Kimberly, RP .

ARTHRITIS AND RHEUMATISM, 2003, 48 (11) :3242-3252

← 1 2 3 →