PARP1 Parylation Promotes Silent Locus Transmission in the Nucleolus: The Suspicion Confirmed

被引：5

作者：

Isabelle, Maxim ^{[1
]}

Gallouzi, Imed-Eddine ^{[2
]}

Poirier, Guy G. ^{[1
]}

机构：

[1] Ctr Rech, Cancer Axis, PQ, Canada

[2] McGill Univ, Goodman Canc Ctr, Dept Biochem, Montreal, PQ, Canada

来源：

MOLECULAR CELL | 2012年 / 45卷 / 06期

关键词：

CHROMATIN; ROLES;

D O I：

10.1016/j.molcel.2012.03.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.

引用

收藏

页码：706 / 707

页数：2

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