Studies with polyfunctionally substituted heteroaromatics: A novel synthesis of substituted 4,8-diaminoisoquinolines as potential antiparasitic agents

被引:16
作者
Al-Omran, F [1 ]
Abou El-Khair, A [1 ]
Elnagdi, MH [1 ]
机构
[1] Kuwait Univ, Fac Sci, Dept Chem, Safat 13060, Kuwait
来源
JOURNAL OF CHEMICAL RESEARCH-S | 1998年 / 12期
关键词
D O I
10.1039/a804639e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
New routes for the synthesis of 4,8-diaminoisoquinolines and pyridine utilizing a 3,4-diaminobut-3-en-2-one (2) as starting material are reported.
引用
收藏
页码:798 / 799
页数:3
相关论文
共 14 条
[1]  
ABOUSHANAB F, 1997, ADV HETEROCYCL CHEM, V68, P181
[2]   1-substituted 3-dimethylaminoprop-2-en-1-ones as building blocks in heterocyclic synthesis: Routes to 6-aryl- and 6-heteroaryl-2H-pyran-2-ones and 6- and 4-arylpyridin-2(1H)-ones [J].
AlOmran, F ;
AlAwadhi, N ;
Khalik, MMA ;
Kaul, K ;
AbuElKhair, A ;
Elnagdi, MH .
JOURNAL OF CHEMICAL RESEARCH-S, 1997, (03) :84-&
[3]   Synthesis of new aryl and heteroaromatic substituted pyridines, pyrazoles, pyrimidines and pyrazolo[3,4-d]pyridazines [J].
AlOmran, F ;
AlAwadi, N ;
AbouElKhair, A ;
Elnagdi, MH .
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1997, 29 (03) :285-292
[4]  
ALOMRAN F, 1997, J CHEM RES M, P601
[5]   ANTIFILARIAL AGENTS .I. EFFECTS OF 4-[(7-CHLORO-4-QUINOLYL)AMINO]-ALPHA-(MONO- AND DIALKYLAMINO)-O-CRESOLS AND RELATED COMPOUNDS AGAINST LITOMOSOIDES CARINII IN GERBILS [J].
ELSLAGER, EF ;
PERRICON.SC ;
TENDICK, FH .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (06) :965-&
[6]  
HUWART JD, 1965, ORG SYNTH, V45, P2
[7]   Benzotriazole-assisted preparations of 2-(substituted amino)pyridines and pyrid-2 ones [J].
Katritzky, AR ;
Belyakov, SA ;
Sorochinsky, AE ;
Henderson, SA ;
Chen, J .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (18) :6210-6214
[8]  
LOIS M, 1993, TROP MED PARASITOL, V87, P409
[9]  
NEWKOME GR, 1982, CONT HETEROCYCLIC CH, P306
[10]  
RAY PS, 1994, HETEROCYCLES, V38, P1361