Synthesis of Chiral Benzoxa(thia)zepine and Pyridoxazepine Derivatives Using Palladium-Catalyzed Intramolecular Aryl Amination Reaction

被引：2

作者：

Das Adhikary, Nirmal ^{[1
]}

Chattopadhyay, Partha ^{[1
]}

机构：

[1] Indian Inst Chem Biol, Div Chem, Kolkata 700032, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 36期

关键词：

Heterocycles; Amination; Cyclization; Palladium; Phosphane; -ligands; HIV-1; REVERSE-TRANSCRIPTASE; FURANOSE DERIVATIVES; D-GLUCOSE; PRIVILEGED STRUCTURES; RADICAL CYCLIZATION; EXPEDIENT APPROACH; AROMATIC RING; EFFICIENT; HETEROCYCLES; REARRANGEMENT;

D O I：

10.1002/ejoc.201101174

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed method employing different bulky biaryl phosphanes as ligands has been developed for the intramolecular amination of aryl bromides and iodides. A variety of aryl halide substrates have been aminated through the intramolecular pathway in good yield using different sugar-derived amines to give furo-benzoxa(thia)zepine and pyridoxazepine derivatives. The method is capable of furnishing chiral, enantiopure benzoxa(thia)zepines and pyridoxazepines of significant biological importance.

引用

页码：7346 / 7354

页数：9

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