Human Umbilical Cord Blood Cells and Diabetes Mellitus: Recent Advances

被引：4

作者：

Reddi, Alluru S. ^{[1
]}

Kothari, Neil ^{[1
]}

Kuppasani, Kishore ^{[1
]}

Ende, Norman ^{[2
,3
]}

机构：

[1] Rutgers New Jersey Med Sch, Dept Med, Newark, NJ 07103 USA

[2] Rutgers New Jersey Med Sch, Dept Pathol, Newark, NJ 07103 USA

[3] Rutgers New Jersey Med Sch, Dept Lab Med, Newark, NJ 07103 USA

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2015年 / 10卷 / 03期

关键词：

beta-cells; clinical trials; diabetes mellitus; differentiation; human umbilical cord blood; stem cells; stem cell educator therapy; MESENCHYMAL STEM-CELLS; INSULIN-PRODUCING CELLS; IMMUNE MODULATION; C-PEPTIDE; TRANSPLANTATION; THERAPY; MARROW; GLYCEMIA; INFUSION; CHILDREN;

D O I：

10.2174/1574888X10666141212122421

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cell therapy for patients with diabetes is an area of great interest to both scientists and clinicians. Human umbilical cord blood cells (HUCBCs) are being increasingly used as a source of stem cells for cell-based therapy for diabetes because these cells can differentiate into pancreatic islet beta-cells. Administration of HUCBCs has been shown to lower blood glucose levels in diabetic animal models. The use of autologous HUCBC transfusion in type 1 diabetic children has not shown any benefit. However, "Stem Cell Educator" therapy has shown promise in long term lowering of blood glucose levels in both type 1 and type 2 diabetic patients. In this review, we will briefly discuss recent advances in HUCBC therapy in the treatment of diabetes and some of its complications.

引用

页码：266 / 270

页数：5

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