Hippocampal Volume Differences Between Healthy Young Apolipoprotein E ε2 and ε4 Carriers

被引：58

作者：

Alexopoulos, Panagiotis ^{[1
,2
]}

Richter-Schmidinger, Tanja ^{[2
]}

Horn, Marco ^{[2
]}

Maus, Sebastian ^{[2
]}

Reichel, Martin ^{[2
]}

Sidiropoulos, Christos ^{[2
,3
]}

Rhein, Cosima ^{[2
]}

Lewczuk, Piotr ^{[2
]}

Doerfler, Arnd ^{[4
]}

Kornhuber, Johannes ^{[2
]}

机构：

[1] Univ Munich, Klinikum Rechts Isar Technischen, Klin Psychiatrie & Psychotherapie, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

[2] Klinikum Friedrich Alexander Univ Erlangen Nurnbe, Dept Psychiat & Psychotherapy, Erlangen, Germany

[3] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

[4] Klinikum Friedrich Alexander Univ Erlangen Nurnbe, Dept Neuroradiol, Erlangen, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2011年 / 26卷 / 02期

关键词：

apolipoprotein E; hippocampal volume; memory function; young healthy individuals; ALLELE;

D O I：

10.3233/JAD-2011-110356

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The apolipoprotein E (APOE) epsilon 4 allele is the major genetic risk factor for the development of late-onset Alzheimer's disease (AD), whereas the presence of the APOE epsilon 2 allele seems to confer protection. Here, we report that healthy young APOE epsilon 4 carriers have statistically significantly smaller hippocampal volumes than APOE epsilon 2 carriers, while no differences were detected between the two groups in memory performance. The difference in hippocampal morphology is cognitively/clinically silent in young adulthood, but could render APOE epsilon 4 carriers more prone to the later development of AD possibly due to lower reserve cognitive capacity.

引用

收藏

页码：207 / 210

页数：4

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