Poly(ADP-ribose) polymerase-1 and ionizing radiation: Sensor, signaller and therapeutic target

被引：34

作者：

Chalmers, AJ ^{[1
]}

机构：

[1] Mt Vernon Hosp, Gray Canc Inst, Northwood HA6 2JR, Middx, England

来源：

CLINICAL ONCOLOGY | 2004年 / 16卷 / 01期

关键词：

D O I：

10.1016/S0936-6555(03)00223-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme that binds rapidly to single and double-strand breaks in DNA and consequently modifies a range of nuclear proteins involved in the cellular response to ionising radiation. PARP-1 knockout mice are highly sensitive to ionising radiation, and inhibition or depletion of PARP-1 brings about modest sensitisation of cells in culture to radiation doses of 2Gy and above. In certain cell lines, chemical inhibition of PARP activity is also associated with marked sensitisation to very low doses of radiation (<0.5 Gy). The mechanisms underlying these effects are discussed, and possible therapeutic applications of PARP-1 manipulation in combination with ionising radiation are considered. (C) 2003 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：29 / 39

页数：11

共 80 条

[1]

Abdelkarim GE, 2001, INT J MOL MED, V7, P255

[2] INTERACTIONS OF POLY(ADP-RIBOSE) WITH NUCLEAR PROTEINS [J].

ALTHAUS, FR ;

BACHMANN, S ;

HOFFERER, L ;

KLECZKOWSKA, HE ;

MALANGA, M ;

PANZETER, PL ;

REALINI, C ;

ZWEIFEL, B .

BIOCHIMIE, 1995, 77 (06) :423-432

[3] POLY(ADP-RIBOSE) CATABOLISM IN MAMMALIAN-CELLS EXPOSED TO DNA-DAMAGING AGENTS [J].

ALVAREZGONZALEZ, R ;

ALTHAUS, FR .

MUTATION RESEARCH, 1989, 218 (02) :67-74

[4] PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase [J].

Amé, JC ;

Rolli, V ;

Schreiber, V ;

Niedergang, C ;

Apiou, F ;

Decker, P ;

Muller, S ;

Hoger, T ;

Murcia, JMD ;

de Murcia, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) :17860-17868

[5] PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression [J].

Augustin, A ;

Spenlehauer, C ;

Dumond, H ;

Murcia, JMD ;

Piel, M ;

Schmit, AC ;

Apiou, F ;

Vonesch, JL ;

Kock, M ;

Bornens, M ;

de Murcia, G .

JOURNAL OF CELL SCIENCE, 2003, 116 (08) :1551-1562

[6]

BANASIK M, 1992, J BIOL CHEM, V267, P1569

[7]

BENJAMIN RC, 1980, J BIOL CHEM, V255, P493

[8] ASSOCIATION OF POLY(ADENOSINE DIPHOSPHORIBOSE) SYNTHESIS WITH DNA DAMAGE AND REPAIR IN NORMAL HUMAN-LYMPHOCYTES [J].

BERGER, NA ;

SIKORSKI, GW ;

PETZOLD, SJ ;

KUROHARA, KK .

JOURNAL OF CLINICAL INVESTIGATION, 1979, 63 (06) :1164-1171

[9] Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells [J].

Bogliolo, M ;

Taylor, RM ;

Caldecott, KW ;

Frosina, G .

ONCOGENE, 2000, 19 (50) :5781-5787

[10] Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage [J].

Boulton, S ;

Kyle, S ;

Durkacz, BW .

CARCINOGENESIS, 1999, 20 (02) :199-203

← 1 2 3 4 5 6 7 8 →