Identification of prognostic genes in colorectal cancer through transcription profiling of multi-stage carcinogenesis

被引:8
作者
An, Ning [1 ]
Zhao, Chen [2 ]
Yu, Zhuang [1 ]
Yang, Xue [1 ]
机构
[1] Qingdao Univ, Dept Oncol, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China
[2] Qingdao Univ, Sch Basic Med, Dept Anat, Qingdao 266071, Shandong, Peoples R China
关键词
colorectal cancer; carcinogenesis; biological network; random walk; prognostic genes; EXPRESSION; SURVIVAL; NEOPLASIA; NETWORKS; MODEL;
D O I
10.3892/ol.2018.9632
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colorectal cancer is a complex multistage process following the adenoma-carcinoma sequence. Additional research on the basis of molecular dysregulations, particularly in the precancerous stage, may provide insight into the realization of potential biomarkers and therapeutic targets for the disease. In the present study, the expression profile of human multistage colorectal mucosa tissues, including healthy, adenoma and adenocarcinoma samples, was downloaded. Genes that were consistently differentially expressed in precancerous tissues and cancer samples were collected. Based on a merged biological network, the biggest connected component composed of these identified genes and their one-step neighbors were retrieved to conduct random walk with restart algorithm, in order to identify genes significantly affected during carcinogenesis. Therefore, 35 genes significantly affected by carcinogenic dysregulation were successfully identified. Survival and Cox analysis indicated that the expression of these genes was an independent prognostic factor confirmed by six cohorts. In summary, based on the transcription profile of multi-stage carcinogenesis and bioinformatics analysis, 35 genes significantly associated with patient survival were successfully identified, which may serve as promising therapeutic targets for the disease.
引用
收藏
页码:432 / 441
页数:10
相关论文
共 41 条
  • [1] Classes of small-world networks
    Amaral, LAN
    Scala, A
    Barthélémy, M
    Stanley, HE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) : 11149 - 11152
  • [2] Discovery of a Novel Immune Gene Signature with Profound Prognostic Value in Colorectal Cancer: A Model of Cooperativity Disorientation Created in the Process from Development to Cancer
    An, Ning
    Shi, Xiaoyu
    Zhang, Yueming
    Lv, Ning
    Feng, Lin
    Di, Xuebing
    Han, Naijun
    Wang, Guiqi
    Cheng, Shujun
    Zhang, Kaitai
    [J]. PLOS ONE, 2015, 10 (09):
  • [3] Colorectal cancer
    Brenner, Hermann
    Kloor, Matthias
    Pox, Christian Peter
    [J]. LANCET, 2014, 383 (9927) : 1490 - 1502
  • [4] Prognostic and Predictive Value of a Malignancy-Risk Gene Signature in Early-Stage Non-Small Cell Lung Cancer
    Chen, Dung-Tsa
    Hsu, Ying-Lin
    Fulp, William J.
    Coppola, Domenico
    Haura, Eric B.
    Yeatman, Timothy J.
    Cress, W. Douglas
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (24): : 1859 - 1870
  • [5] A recellularized human colon model identifies cancer driver genes
    Chen, Huanhuan Joyce
    Wei, Zhubo
    Sun, Jian
    Bhattacharya, Asmita
    Savage, David J.
    Serda, Rita
    Mackeyev, Yuri
    Curley, Steven A.
    Bu, Pengcheng
    Wang, Lihua
    Chen, Shuibing
    Cohen-Gould, Leona
    Huang, Emina
    Shen, Xiling
    Lipkin, Steven M.
    Copeland, Neal G.
    Jenkins, Nancy A.
    Shuler, Michael L.
    [J]. NATURE BIOTECHNOLOGY, 2016, 34 (08) : 845 - +
  • [6] A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes
    Chen, Lei
    Chu, Chen
    Kong, Xiangyin
    Huang, Guohua
    Huang, Tao
    Cai, Yu-Dong
    [J]. PLOS ONE, 2015, 10 (03):
  • [7] A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma
    Chen, Ron
    Khatri, Purvesh
    Mazur, Pawel K.
    Polin, Melanie
    Zheng, Yanyan
    Vaka, Dedeepya
    Hoang, Chuong D.
    Shrager, Joseph
    Xu, Yue
    Vicent, Silvestre
    Butte, Atul J.
    Sweet-Cordero, E. Alejandro
    [J]. CANCER RESEARCH, 2014, 74 (10) : 2892 - 2902
  • [8] Mammary carcinoma behavior is programmed in the precancer stem cell
    Damonte, Patrizia
    Hodgson, J. Graeme
    Chen, Jane Qian
    Young, Lawrence J. T.
    Cardiff, Robert D.
    Borowsky, Alexander D.
    [J]. BREAST CANCER RESEARCH, 2008, 10 (03):
  • [9] Ephrin B2 Receptor and Microsatellite Status in Lymph Node-Positive Colon Cancer Survival
    Drucker, Arik
    Arnason, Thomas
    Yan, Sen Rong
    Aljawad, Mohammed
    Thompson, Kara
    Huang, Weei-Yuarn
    [J]. TRANSLATIONAL ONCOLOGY, 2013, 6 (05) : 520 - 527
  • [10] Colorectal Cancer Biomarkers: Where Are We Now?
    Gonzalez-Pons, Maria
    Cruz-Correa, Marcia
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015