Dynamic stem cell heterogeneity

被引：83
作者：
Krieger, Teresa [1 ,2 ]
Simons, Benjamin D. [1 ,2 ,3 ]
机构：
[1] Univ Cambridge, Wellcome Trust, Canc Res UK, Gurdon Inst, Cambridge CB2 1QN, England
[2] Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England
[3] Univ Cambridge, Wellcome Trust MRC Stem Cell Inst, Cambridge CB2 1QR, England
来源：
DEVELOPMENT | 2015年 / 142卷 / 08期
基金：
英国惠康基金; 英国工程与自然科学研究理事会;
关键词：
Adult stem cell; Gene heterogeneity; Germ line; Intestine; Lineage tracing; Tissue homeostasis; LABEL-RETAINING CELLS; MOUSE SMALL INTESTINE; SELF-RENEWAL; IN-VIVO; NEUTRAL COMPETITION; PROGENITOR CELLS; MALE GERMLINE; NICHE; EXPRESSION; CRYPT;
D O I：
10.1242/dev.101063
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recent lineage-tracing studies based on inducible genetic labelling have emphasized a crucial role for stochasticity in the maintenance and regeneration of cycling adult tissues. These studies have revealed that stem cells are frequently lost through differentiation and that this is compensated for by the duplication of neighbours, leading to the consolidation of clonal diversity. Through the combination of long-term lineage-tracing assays with short-term in vivo live imaging, the cellular basis of this stochastic stem cell loss and replacement has begun to be resolved. With a focus on mammalian spermatogenesis, intestinal maintenance and the hair cycle, we review the role of dynamic heterogeneity in the regulation of adult stem cell populations.
引用
收藏
页码：1396 / 1406
页数：11
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