Psoriatic juvenile idiopathic arthritis: a tale of two subgroups

被引:53
作者
Stoll, Matthew L. [1 ]
Punaro, Marilynn [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dept Rheumatol, Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA
基金
美国国家卫生研究院;
关键词
age of onset; juvenile idiopathic arthritis; psoriatic arthritis; INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; DISTAL INTERPHALANGEAL JOINT; ENTHESITIS-RELATED ARTHRITIS; RHEUMATOID-ARTHRITIS; CLASSIFICATION CRITERIA; ANKYLOSING-SPONDYLITIS; SUSCEPTIBILITY LOCI; ULCERATIVE-COLITIS; DOUBLE-BLIND;
D O I
10.1097/BOR.0b013e328348b278
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review The International League of Associations for Rheumatology criteria parse out juvenile idiopathic arthritis (JIA) into seven groups, with the aim of creating homogeneous subgroups suitable for clinical and research evaluation. However, prior studies have shown that psoriatic JIA (psJIA) may be a heterogeneous entity. Recent findings PsJIA is composed of two subgroups, differentiated by age at onset. Older children with psJIA have features of spondyloarthritis, including relative male preponderance, increased risk of axial involvement, and enthesitis. Extrapolating from studies on adults with psoriatic arthritis, the mechanism of older-onset PsJIA appears to involve autoinflammatory dysregulation centered at the synovial-entheseal complex; there may also be a role for gut inflammation in a subset of patients. In contrast, patients with early-onset PsJIA bear similarities to early-onset oligoarticular and polyarticular JIA patients, including female preponderance, antinuclear antibody (ANA) positivity, and certain human leukocyte antigen types, suggesting a possible role for traditional autoimmune mechanisms. Both groups, however, share a high frequency of dactylitis. Summary This review demonstrates that PsJIA is a heterogeneous entity, with different clinical, genetic, and possibly pathophysiological features. Future studies are needed to explore the mechanisms of arthritis in both subgroups, particularly in the early-onset children.
引用
收藏
页码:437 / 443
页数:7
相关论文
共 90 条
[1]   CLINICALLY SILENT INFLAMMATORY GUT LESIONS IN UNDIFFERENTIATED SPONDYLOARTHROPATHIES [J].
ALTOMONTE, L ;
ZOLI, A ;
VENEZIANI, A ;
MIRONE, L ;
SANTACESARIA, G ;
CHIARELLI, C ;
FEDERICO, F ;
MASSI, G ;
MAGARO, M .
CLINICAL RHEUMATOLOGY, 1994, 13 (04) :565-570
[2]  
AMOR B, 1990, REV RHUM, V57, P85
[3]  
[Anonymous], [No title captured]
[4]  
ANSELL B, 1993, BRIT J RHEUMATOL, V32, P836
[5]   DIAGNOSIS OF PROBABLE STILLS DISEASE AND ITS OUTCOME [J].
ANSELL, BM ;
BYWATERS, EG .
ANNALS OF THE RHEUMATIC DISEASES, 1962, 21 (03) :253-&
[6]  
Antoni CE, 2008, J RHEUMATOL, V35, P869
[7]   Comparison of effectiveness and safety of infliximab, etanercept, and adalimumab in psoriatic arthritis patients who experienced an inadequate response to previous disease-modifying antirheumatic drugs [J].
Atteno, Mariangela ;
Peluso, Rosario ;
Costa, Luisa ;
Padula, Stefania ;
Iervolino, Salvatore ;
Caso, Francesco ;
Sanduzzi, Alessandro ;
Lubrano, Ennio ;
Del Puente, Antonio ;
Scarpa, Raffaele .
CLINICAL RHEUMATOLOGY, 2010, 29 (04) :399-403
[8]   Comparison of Patients with Juvenile Psoriatic Arthritis and Nonpsoriatic Juvenile Idiopathic Arthritis: How Different Are They? [J].
Aviel, Yonatan Butbul ;
Tyrrell, Pascal N. ;
Schneider, Rayfel ;
Dhillon, Sandeep ;
Feldman, Brian M. ;
Laxer, Ronald M. ;
Saurenmann, Rotraud K. ;
Spiegel, Lynn ;
Cameron, Bonnie ;
Tse, Shirley M. ;
Silverman, Earl D. .
JOURNAL OF RHEUMATOLOGY, 2009, 36 (09) :2033-2041
[9]   Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].
Barrett, Jeffrey C. ;
Hansoul, Sarah ;
Nicolae, Dan L. ;
Cho, Judy H. ;
Duerr, Richard H. ;
Rioux, John D. ;
Brant, Steven R. ;
Silverberg, Mark S. ;
Taylor, Kent D. ;
Barmada, M. Michael ;
Bitton, Alain ;
Dassopoulos, Themistocles ;
Datta, Lisa Wu ;
Green, Todd ;
Griffiths, Anne M. ;
Kistner, Emily O. ;
Murtha, Michael T. ;
Regueiro, Miguel D. ;
Rotter, Jerome I. ;
Schumm, L. Philip ;
Steinhart, A. Hillary ;
Targan, Stephan R. ;
Xavier, Ramnik J. ;
Libioulle, Cecile ;
Sandor, Cynthia ;
Lathrop, Mark ;
Belaiche, Jacques ;
Dewit, Olivier ;
Gut, Ivo ;
Heath, Simon ;
Laukens, Debby ;
Mni, Myriam ;
Rutgeerts, Paul ;
Van Gossum, Andre ;
Zelenika, Diana ;
Franchimont, Denis ;
Hugot, Jean-Pierre ;
de Vos, Martine ;
Vermeire, Severine ;
Louis, Edouard ;
Cardon, Lon R. ;
Anderson, Carl A. ;
Drummond, Hazel ;
Nimmo, Elaine ;
Ahmad, Tariq ;
Prescott, Natalie J. ;
Onnie, Clive M. ;
Fisher, Sheila A. ;
Marchini, Jonathan ;
Ghori, Jilur .
NATURE GENETICS, 2008, 40 (08) :955-962
[10]   The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites [J].
Benjamin, M ;
McGonagle, D .
JOURNAL OF ANATOMY, 2001, 199 :503-526