Synthesis and Antinociceptive Activity of Substituted 5-(Het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones

被引：21

作者：

Lipin, D. V. ^{[1
]}

Denisova, E. I. ^{[1
,2
]}

Devyatkin, I. O. ^{[2
]}

Okoneshnikova, E. A. ^{[1
]}

Shipilovskikh, D. A. ^{[1
,3
]}

Makhmudov, R. R. ^{[1
,4
]}

Igidov, N. M. ^{[2
]}

Shipilovskikh, S. A. ^{[1
,5
]}

机构：

[1] Perm State Univ, Perm 614990, Russia

[2] Perm State Pharmaceut Acad, Perm 614990, Russia

[3] Perm Natl Res Polytech Univ, Perm 614990, Russia

[4] Fed Res Ctr Med & Prevent Technol Managing Publ H, Perm 614045, Russia

[5] ITMO Univ, Sch Phys & Engn, St Petersburg 197101, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 12期

关键词：

2; 4-dioxobutanoic acids; 3-imino(hydrazono)furan-2(3H)-one; antinociceptive activity; CAP-SNATCHING ENDONUCLEASE; DIKETO ACIDS;

D O I：

10.1134/S1070363221120161

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compounds was studied.

引用

页码：2469 / 2474

页数：6