Palladium-catalyzed oxidative amidation of quinoxalin-2(1H)-ones with acetonitrile: a highly efficient strategy toward 3-amidated quinoxalin-2(1H)-ones

被引：45

作者：

Yuan, Jinwei ^{[1
,2
]}

Liu, Shuainan ^{[2
]}

Xiao, Yongmei ^{[2
]}

Mao, Pu ^{[2
]}

Yang, Liangru ^{[2
]}

Qu, Lingbo ^{[2
,3
]}

机构：

[1] State Adm Grain, Engn Technol Res Ctr Grain & Oil Food, Zhengzhou 450001, Henan, Peoples R China

[2] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China

[3] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 04期

关键词：

C-H AMIDATION; ARYLBORONIC ACIDS; ARYL KETONES; NITRILES; ACTIVATION; ARYLATION; AMIDES; ROUTE; DECARBOXYLATION; ANNULATION;

D O I：

10.1039/c8ob03061h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and convenient palladium-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with acetonitrile was developed to synthesize 3-amidated quinoxalin-2(1H)-ones. A series of 3-acetamino quinoxalin-2(1H)-one derivatives were constructed with good to excellent yields. This methodology provided a practical approach to various 3-acetamino quinoxalin-2(1H)-ones from the readily available starting material acetonitrile.

引用

页码：876 / 884

页数：9

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