Dendritic cell maturation by innate lymphocytes:: coordinated stimulation of innate and adaptive immunity

被引：299

作者：

Münz, C

Steinman, RM

Fujii, SI

机构：

[1] Rockefeller Univ, Lab Virol Immunobiol, New York, NY 10021 USA

[2] Rockefeller Univ, Christopher H Browne Ctr Immunol & Immune Dis, New York, NY 10021 USA

[3] Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA

[4] RIKEN, Res Ctr Allergy & Immunol, Res Unit Cellular Immunotherapy, Yokohama, Kanagawa 2300045, Japan

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 02期

关键词：

D O I：

10.1084/jem.20050810

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes-natural killer (NK), natural killer T (NKT), and gamma delta T cells - also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.

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页码：203 / 207

页数：5

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