The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing

被引：27

作者：

Chen, Cheng ^{[1
]}

Meng, Ziyu ^{[2
,3
]}

Ren, He ^{[4
]}

Zhao, Na ^{[4
]}

Shang, Ruoyu ^{[1
]}

He, Weifeng ^{[1
]}

Hao, Jianlei ^{[5
,6
]}

机构：

[1] Third Mil Med Univ, State Key Lab Trauma Burns & Combined Injury, Affiliated Hosp 1, Army Med Univ,Chongqing Key Lab Dis Prote,Inst Bu, Chongqing 400038, Peoples R China

[2] Tianjin Med Univ, NHC Key Lab Hormones & Dev, Tianjin Key Lab Metab Dis, Chu Hsien I Mem Hosp, Tianjin 300134, Peoples R China

[3] Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin 300134, Peoples R China

[4] Tianjin Med Univ, Tianjin Med Univ Gen Hosp, Dept Gen Surg, Tianjin 300052, Peoples R China

[5] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Inst Translat Med, Zhuhai 519000, Guangdong, Peoples R China

[6] Jinan Univ, Fac Med Sci, Biomed Translat Res Inst, Guangzhou 510632, Guangdong, Peoples R China

来源：

BURNS & TRAUMA | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Dendritic epidermal T cells; Wound healing; gamma delta T cells; Cytokines; Cytokine receptors; Signalling pathways; Skin; KERATINOCYTE GROWTH-FACTOR; EPITHELIAL-CELLS; SELECTIN LIGANDS; UP-REGULATION; IN-VIVO; RECEPTOR; EXPRESSION; SKIN; TCR; NKG2D;

D O I：

10.1093/burnst/tkab009

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The epidermis is the outermost layer of skin and the first barrier against invasion. Dendritic epidermal T cells (DETCs) are a subset of gamma delta T cells and an important component of the epidermal immune microenvironment. DETCs are involved in skin wound healing, malignancy and autoimmune diseases. DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing. Therefore, an understanding of their development, activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing. Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.

引用

页数：12

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