Drug release studies of titanium-based polyethylene glycol coating as a multifunctional substrate

Thrombosis is the fundamental basis of a catastrophe of cardiovascular and other blood-reaching biomedical gadgets. Drug-eluting inserts for the nearby conveyance of anti-infection agents at clinical locales are believed to be promising in averting cardiovascular diseases. Titanium and its compositions have been generally utilized for blood-reaching biomedical devices because of its excellent biocompatibility; however, their blood compatibility should be improved. In this present study, titanium surface was modified with sodium hydroxide (NaOH) which generate hydroxyl group (-OH) groups thereby facilitating encapsulation of aspirin (200 mg) accompanied by the coating of various percentage (0.5%,1%,2%, 2.5% and 3% w/v) of polyethylene glycol (PEG) (MW-20,000). The drug release amount could be managed by the aspirin loading quantity and the PEG covering thickness. The measure of aspirin delivered in phosphate buffer solution (pH = 7.4) was resolved by utilizing a UV-Vis spectrophotometer. Aspirin was released continuously till 8 h for 0.5% to 2.5% PEG coating whereas for 2.5% and 3% PEG coating it has been released till 9 h. The aspirin release rate from the titanium substrates was performed by fitting the data to the Ritger-Peppas equation. The diffusional type n for a lower percentage of PEG coating indicates nonfickian transport because of swelling of the PEG layer whereas a higher percentage of PEG coating indicates the super case II transport mechanism in aspirin discharge. Therefore, the developed Ti-based substrates have the potential to elute drugs continuously thereby making them suitable for cardiovascular implants. (c) 2021 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the 12th National Conference on Recent Advancements in Biomedical Engineering.