Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media

被引：3
作者：
Tatar, A. [1 ]
Korkmaz, M. [5 ]
Yayla, M. [2 ]
Gozeler, M. S. [1 ]
Mutlu, V. [1 ]
Halici, Z. [2 ]
Uslu, H. [3 ]
Korkmaz, H. [5 ]
Selli, J. [4 ]
机构：
[1] Ataturk Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Erzurum, Turkey
[2] Ataturk Univ, Fac Med, Dept Pharmacol, Erzurum, Turkey
[3] Ataturk Univ, Fac Med, Dept Microbiol, Erzurum, Turkey
[4] Ataturk Univ, Fac Med, Dept Histol & Embryol, Erzurum, Turkey
[5] Ordu Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Ordu, Turkey
来源：
JOURNAL OF LARYNGOLOGY AND OTOLOGY | 2016年 / 130卷 / 07期
关键词：
Otitis Media; Reactive Oxygen Species; Alpha-Lipoic Acid; Inflammation; Guinea Pig; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; MIDDLE-EAR; TISSUE-DAMAGE; CELLS; RATS; EXPRESSION; INDUCTION; EFFUSION; CHILDREN;
D O I：
10.1017/S0022215116001183
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objectives: To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media. Methods: Twenty-five guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid plus penicillin G. Tissue samples were histologically analysed, and oxidative parameters in tissue samples were measured and compared between groups. Results: The epithelial integrity was better preserved, and histological signs of inflammation and secretory metaplasia were decreased, in all groups compared to the saline treated otitis group. In the alpha-lipoic acid plus penicillin G treated otitis group, epithelial integrity was well preserved and histological findings of inflammation were significantly decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group. Conclusion: Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media.
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页码：616 / 623
页数：8
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