Differential effects of endocannabinoids on[3H]-GABA uptake in the rat globus pallidus

被引：22

作者：

Venderova, K

Brown, TM

Brotchie, JM

机构：

[1] Toronto Western Hosp, Toronto Western Res Inst, Toronto, ON M5T 2S8, Canada

[2] Univ Manchester, Sch Biol Sci, Manchester, Lancs, England

来源：

EXPERIMENTAL NEUROLOGY | 2005年 / 194卷 / 01期

关键词：

endocannabinoid; Parkinson's disease; globus pallidus; basal ganglia; cannabinoid; CB1; anandamide; 2-AG; noladin ether; GABA;

D O I：

10.1016/j.expneurol.2005.02.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the globus pallidus, cannabinoid CB1 receptors are localized pre-synaptically on GABAergic neurons, We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether. on the uptake of [H-3]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [H-3]-GABA uptake (by 40.8 +/- 8.0% and 38 +/- 12.5%). The effect ct of 2-AG was blocked by the cannabinoid CB1 receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55.212-2 had in eflect on [H-3]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders. such as Parkinson's disease. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：284 / 287

页数：4

共 25 条

[21] Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism [J].