Mechanism and Regulation of Meiotic Recombination Initiation

被引：293

作者：

Lam, Isabel ^{[1
,2
]}

Keeney, Scott ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Louis V Gerstner Jr Grad Sch Biomed Sci, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2015年 / 7卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRAND BREAKS; SISTER-CHROMATID COHESION; SYNAPTONEMAL COMPLEX-FORMATION; LINEAR ELEMENT FORMATION; DNA-REPLICATION; HISTONE H3; C-ELEGANS; HOMOLOGOUS RECOMBINATION; DSB FORMATION; CHROMOSOME SYNAPSIS;

D O I：

10.1101/cshperspect.a016634

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appropriate, findings in different organisms are discussed to highlight evolutionary conservation or divergence.

引用

页数：24

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