IL8 and Cathepsin B as Melanoma Serum Biomarkers

被引：42

作者：

Zhang, Hongtao ^{[1
]}

Fu, Ting ^{[1
]}

McGettigan, Suzanne ^{[2
]}

Kumar, Suresh ^{[1
]}

Liu, Shujing ^{[1
]}

Speicher, David ^{[3
]}

Schuchter, Lynn ^{[2
]}

Xu, Xiaowei ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Hosp Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA

[3] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 03期

关键词：

IL-8; cathepsin B; melanoma; serum interference; TUMOR-GROWTH; ANTIBODIES; INTERLEUKIN-8; INTERFERENCES; ANGIOGENESIS; INHIBITION; ACTIVATION; PROGRESS; MARKERS; IL-8;

D O I：

10.3390/ijms12031505

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false readouts in immunological tests. Here we show that, after using a special buffer to eliminate the serum interference, IL-8 and cathepsin B levels were significantly elevated in melanoma patients (p < 0.05). More importantly, the combination of IL-8 and cathepsin B were also studied as a prognosis marker for melanoma mortality. Our study provides a novel approach to examine serum biomarkers.

引用

页码：1505 / 1518

页数：14

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