Histone methylation and vascular biology

被引：53
作者：
Wei, Xiang [1 ,2 ,3 ,4 ]
Yi, Xin [5 ]
Zhu, Xue-Hai [1 ,2 ,3 ,4 ]
Jiang, Ding-Sheng [1 ,2 ,3 ,4 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Div Cardiothorac & Vasc Surg, 1095 Jiefang Ave, Wuhan 430030, Peoples R China
[2] Minist Educ, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China
[3] NHC Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China
[4] Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China
[5] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Hubei, Peoples R China
来源：
CLINICAL EPIGENETICS | 2020年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Histone methylation; Histone methyltransferase; Demethylase; Atherosclerosis; Intimal hyperplasia; Aortic dissection; aneurysm; Pulmonary arterial hypertension; Diabetic angiopathy; Cancer angiogenesis; SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE SYNTHASE; PULMONARY ARTERIAL-HYPERTENSION; ABDOMINAL AORTIC-ANEURYSM; ARGININE METHYLATION; CARDIAC-HYPERTROPHY; EPIGENETIC CONTROL; DNA METHYLATION; GENE-EXPRESSION; RAT MODEL;
D O I：
10.1186/s13148-020-00826-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain homeostasis within the vasculature. Recent studies have greatly expanded our understanding of the regulation of vasculature development and vascular-related diseases at the epigenetic level, including by protein posttranslational modifications, DNA methylation, and noncoding RNAs. Integrating epigenetic mechanisms into the pathophysiologic conceptualization of complex and multifactorial vascular-related diseases may provide promising therapeutic approaches. Several reviews have presented detailed discussions of epigenetic mechanisms not including histone methylation in vascular biology. In this review, we primarily discuss histone methylation in vascular development and maturity, and in vascular diseases.
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页数：17
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