Transformation of dendritic cells from plasmacytoid to myeloid in a leukemic plasmacytoid dendritic cell line (PMDC05)

被引：14

作者：

Watanabe, Norihiro ^{[2
,4
]}

Narita, Miwako

Yamahira, Akie

Nakamura, Takeshi

Tochiki, Nozomi

Saitoh, Anri ^{[2
]}

Kaji, Masami

Hashimoto, Shigeo ^{[2
]}

Furukawa, Tatsuo ^{[3
]}

Toba, Ken ^{[2
]}

Fuse, Ichiro ^{[5
]}

Aizawa, Yoshifusa ^{[2
]}

Takahashi, Masuhiro ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Hlth Sci, Lab Hematol & Oncol, Chuou Ku, Niigata 9518518, Japan

[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Hematol, Niigata 9518518, Japan

[3] Niigata Univ, Grad Sch Med & Dent Sci, Div Stem Cell Transplantat, Niigata 9518518, Japan

[4] Japan Soc Promot Sci, Tokyo, Japan

[5] Niigata Univ, Med & Dent Gen Hosp, Biosci Med Res Ctr, Niigata 9518518, Japan

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 11期

基金：

日本学术振兴会;

关键词：

Leukemic plasmacytoid dendritic cell line; Plasmacytoid dendritic cell; Myeloid dendritic cell; Transformation; TOLL-LIKE RECEPTORS; BONE-MARROW; LYMPHOID PROGENITORS; PREDENDRITIC CELLS; HUMAN THYMUS; IFN-ALPHA; IN-VITRO; T-CELLS; SUBSETS; PRECURSORS;

D O I：

10.1016/j.leukres.2010.03.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the transformation from pDCs to mDCs in a pDC line (PMDC05) which was established from a patient with pDC leukemia in our laboratory. PMDC05 cells were separated into two fractions according to the expression of BDCA1 and CD123. BDCA1(-)CD123(+) cells were found to be pDC-like cells by their morphology, surface phenotypes, mRNA expression and the function. In addition, BDCA1(-)CD123(+) cells were demonstrated to have a proliferating capacity and revealed the ability to transform to BDCA1(+)CD123(-) cells which showed mDC-like properties. Our data demonstrated the possibility of transformation from pDCs to mDCs in human DC lineage. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1517 / 1524

页数：8

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