Transformation of dendritic cells from plasmacytoid to myeloid in a leukemic plasmacytoid dendritic cell line (PMDC05)

被引：14
作者：
Watanabe, Norihiro [2 ,4 ]
Narita, Miwako
Yamahira, Akie
Nakamura, Takeshi
Tochiki, Nozomi
Saitoh, Anri [2 ]
Kaji, Masami
Hashimoto, Shigeo [2 ]
Furukawa, Tatsuo [3 ]
Toba, Ken [2 ]
Fuse, Ichiro [5 ]
Aizawa, Yoshifusa [2 ]
Takahashi, Masuhiro [1 ]
机构：
[1] Niigata Univ, Grad Sch Hlth Sci, Lab Hematol & Oncol, Chuou Ku, Niigata 9518518, Japan
[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Hematol, Niigata 9518518, Japan
[3] Niigata Univ, Grad Sch Med & Dent Sci, Div Stem Cell Transplantat, Niigata 9518518, Japan
[4] Japan Soc Promot Sci, Tokyo, Japan
[5] Niigata Univ, Med & Dent Gen Hosp, Biosci Med Res Ctr, Niigata 9518518, Japan
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 11期
基金：
日本学术振兴会;
关键词：
Leukemic plasmacytoid dendritic cell line; Plasmacytoid dendritic cell; Myeloid dendritic cell; Transformation; TOLL-LIKE RECEPTORS; BONE-MARROW; LYMPHOID PROGENITORS; PREDENDRITIC CELLS; HUMAN THYMUS; IFN-ALPHA; IN-VITRO; T-CELLS; SUBSETS; PRECURSORS;
D O I：
10.1016/j.leukres.2010.03.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the transformation from pDCs to mDCs in a pDC line (PMDC05) which was established from a patient with pDC leukemia in our laboratory. PMDC05 cells were separated into two fractions according to the expression of BDCA1 and CD123. BDCA1(-)CD123(+) cells were found to be pDC-like cells by their morphology, surface phenotypes, mRNA expression and the function. In addition, BDCA1(-)CD123(+) cells were demonstrated to have a proliferating capacity and revealed the ability to transform to BDCA1(+)CD123(-) cells which showed mDC-like properties. Our data demonstrated the possibility of transformation from pDCs to mDCs in human DC lineage. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1517 / 1524
页数：8
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