Transformation of dendritic cells from plasmacytoid to myeloid in a leukemic plasmacytoid dendritic cell line (PMDC05)

被引：14
|
作者：
Watanabe, Norihiro [2 ,4 ]
Narita, Miwako
Yamahira, Akie
Nakamura, Takeshi
Tochiki, Nozomi
Saitoh, Anri [2 ]
Kaji, Masami
Hashimoto, Shigeo [2 ]
Furukawa, Tatsuo [3 ]
Toba, Ken [2 ]
Fuse, Ichiro [5 ]
Aizawa, Yoshifusa [2 ]
Takahashi, Masuhiro [1 ]
机构：
[1] Niigata Univ, Grad Sch Hlth Sci, Lab Hematol & Oncol, Chuou Ku, Niigata 9518518, Japan
[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Hematol, Niigata 9518518, Japan
[3] Niigata Univ, Grad Sch Med & Dent Sci, Div Stem Cell Transplantat, Niigata 9518518, Japan
[4] Japan Soc Promot Sci, Tokyo, Japan
[5] Niigata Univ, Med & Dent Gen Hosp, Biosci Med Res Ctr, Niigata 9518518, Japan
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 11期
基金：
日本学术振兴会;
关键词：
Leukemic plasmacytoid dendritic cell line; Plasmacytoid dendritic cell; Myeloid dendritic cell; Transformation; TOLL-LIKE RECEPTORS; BONE-MARROW; LYMPHOID PROGENITORS; PREDENDRITIC CELLS; HUMAN THYMUS; IFN-ALPHA; IN-VITRO; T-CELLS; SUBSETS; PRECURSORS;
D O I：
10.1016/j.leukres.2010.03.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the transformation from pDCs to mDCs in a pDC line (PMDC05) which was established from a patient with pDC leukemia in our laboratory. PMDC05 cells were separated into two fractions according to the expression of BDCA1 and CD123. BDCA1(-)CD123(+) cells were found to be pDC-like cells by their morphology, surface phenotypes, mRNA expression and the function. In addition, BDCA1(-)CD123(+) cells were demonstrated to have a proliferating capacity and revealed the ability to transform to BDCA1(+)CD123(-) cells which showed mDC-like properties. Our data demonstrated the possibility of transformation from pDCs to mDCs in human DC lineage. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1517 / 1524
页数：8
相关论文
共 50 条
  • [1] Transformation of dendritic cells from plasmacytoid to myeloid in leukemic plasmacytoid dendritic cell line (PMDC05) established from a patient with CD4+CD56+acute leukemia
    Watanabe, N.
    Narita, M.
    Tochiki, N.
    Saitoh, A.
    Satoh, N.
    Hashimoto, S.
    Koike, T.
    Takahashi, M.
    EXPERIMENTAL HEMATOLOGY, 2007, 35 (09) : 100 - 100
  • [2] CHARACTERIZATION OF LEUKEMIC PLASMACYTOID DENDRITIC CELL LINE (PMDC05) AND ITS APPLICATION AS ARTIFICIAL ANTIGEN PRESENTING CELLS
    Watanabe, N.
    Narita, M.
    Yamahira, A.
    Nakamura, T.
    Saitoh, A.
    Tochiki, N.
    Kaji, M.
    Hashimoto, S.
    Fuse, I.
    Aizawa, Y.
    Takahashi, M.
    EXPERIMENTAL HEMATOLOGY, 2009, 37 (09) : S93 - S93
  • [3] A leukemic plasmacytoid dendritic cell line (PMDC05) as potent antigen presenting cells for anti-tumor cellular immunothrerapy
    Yamahira, Akie
    Narita, Miwako
    Nakamura, Takeshi
    Watanabe, Norihiro
    Kaji, Masami
    Taniguchi, Tomoyo
    Hashimoto, Shigeo
    Takahashi, Masuhiro
    JOURNAL OF IMMUNOLOGY, 2010, 184
  • [4] Activation of the Leukemia Plasmacytoid Dendritic Cell Line PMDC05 by Toho-1, a Novel IDO Inhibitor
    Yamahira, Akie
    Narita, Miwako
    Iwabuchi, Minami
    Uchiyama, Takayoshi
    Iwaya, Shunpei
    Ohiwa, Rie
    Nishizawa, Yoshinori
    Suzuki, Takafumi
    Yokoyama, Yusaku
    Hashimoto, Shigeo
    Takizawa, Jun
    Sone, Hirohito
    Takahashi, Masuhiro
    ANTICANCER RESEARCH, 2014, 34 (08) : 4021 - 4028
  • [5] Human plasmacytoid dendritic cell line (PMDC05) established from a patient with CD4+CD56+ acute leukemia
    Narita, M
    Tochiki, N
    Hashimoto, S
    Sekiguchi, A
    Watanabe, N
    Yokoyama, A
    Saitoh, A
    Tsuchiyama, J
    Yano, T
    Masuko, M
    Toba, K
    Furukawa, T
    Aizawa, Y
    Takahashi, M
    BLOOD, 2005, 106 (11) : 162B - 162B
  • [6] Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene
    Takahashi, Masuhiro
    Yamahira, Akie
    Iwabuchi, Minami
    Satoh, Naoya
    Uchiyama, Takayoshi
    Hashimoto, Shigeo
    Bogan, Brooke
    Faure, Emmanuelle
    Kasahara, Noriyuki
    Narita, Miwako
    JOURNAL OF IMMUNOLOGY, 2013, 190
  • [7] Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene
    Yamahira, Akie
    Narita, Miwako
    Ishii, Kayoko
    Jayathilake, R. M. Chamila
    Iwabuchi, Minami
    Satoh, Naoya
    Uchiyama, Takayoshi
    Taniguchi, Tomoyo
    Hashimoto, Shigeo
    Kasahara, Noriyuki
    Faure, Emmanuelle
    Bogan, Brooke
    Takizawa, Jun
    Sone, Hirohito
    Takahashi, Masuhiro
    LEUKEMIA RESEARCH, 2012, 36 (12) : 1541 - 1546
  • [8] A leukemic plasmacytoid dendritic cell line, PMDC05, with the ability to secrete IFN-α by stimulation via Toll-like receptors and present antigens to naive T cells
    Narita, Miwako
    Watanabe, Norihiro
    Yamahira, Akie
    Hashimoto, Shigeo
    Tochiki, Nozomi
    Saitoh, Anri
    Kaji, Masami
    Nakamura, Takeshi
    Furukawa, Tatsuo
    Toba, Ken
    Fuse, Ichiro
    Aizawa, Yoshifusa
    Takahashi, Masuhiro
    LEUKEMIA RESEARCH, 2009, 33 (09) : 1224 - 1232
  • [9] Human plasmacytoid dendritic cell like leukemia cell line (PMDC05) established from a patient with CD4+CD56+ acute leukemia.
    Narita, Miwako
    Tochiki, Nozomi
    Watanabe, Norihiro
    Saitoh, Anti
    Hashimoto, Shigeo
    Tsuchiyama, Junjiro
    Furukawa, Tatsuo
    Aoki, Sadao
    Fuse, Ichiro
    Aizawa, Yoshifusa
    Takahashi, Masubiro
    BLOOD, 2006, 108 (11) : 192B - 192B
  • [10] Identification of a leukemic counterpart of the ''plasmacytoid dendritic cells".
    Chaperot, L
    Bendriss, N
    Gressin, R
    Bensa, JC
    Sotto, JJ
    Brière, F
    Plumas, J
    Jacob, MC
    BLOOD, 2000, 96 (11) : 316A - 316A
12345